EFEKTIVITAS INFUSA DAUN ADAS (Foeniculum vulgare L.) PADA TIKUS PUTIH (Rattus sp.) PASCA MELAHIRKAN TERHADAP PERTUMBUHAN ANAKAN

Adas leaf (Foeniculum vulgare L.) was known by the people around the mountain sides of Merbabu as one type of vegetable to increase breast milk secretion. Increased breast milk secretion has positive effect on pups development in early period of life. The aim of this study is to determine the effect of infusion of adas leaves, the effective dose of infusion against the growth of body weight and body length of pups and the levels of flavonoids, steroids, and stigmasterol on adas leaf. The study was conducted using 12 post-partum rats that have each 5 pups. White rats were divided into 4 groups: control group; the G1 (20 grams/300 ml dose infusion); the G2 (40 grams/300 ml dose infusion); and G3(60 grams/300 ml dose infusion). Each group consisted of three replications. All of rats mother treated with the adas leaves by infuse feeding (sonde). Adas leaves was infused by 1 ml for 2 times a day on the rats mother (morning and evening). Rats mother were given pellets and also drinking water by adlibitum. Both mother and inbred rats were weighed, length of its body weight was measured every 5 days for 15 days. Data were analyzed by Analysis of Variance (ANOVA) two way and continued by Duncan Multiple Range Test (DMRT). Quantitatively measurements of total flavonoids, steroids and stigmasterol of adas leaves analyzed using Thin Layer Chromatography (TLC). The results showed that infusion of adas leaves significant difference in the growth of body weight and body length between control and treatment groups (p < 0,05). A dose of 60 grams/300 ml of distilled water can effectively increase the growth of body weight and body length of pups. Levels of total flavonoids, steroids and stigmasterol of adas leaves, respectively, are 0,43 %, 0,029 %, and < 0,011 %