Evaluation antidiabetic activity of various leaf extracts of Pluchea indica Less

Pluchea indica Less leaf extracts of various solvents (methanol, water, ethyl acetate) proven have antioxidant ability using DPPH radical scavenging effect, reducing power, total phenolic content and total flavonoid. However anti-diabetic ability and toxicity level of each extract have not even determined. This study was conducted to determine the effect of different polarity of solvent to phytochemical screening that cause reducing of blood glucose and influence toxicity level of laboratory animal.Our results showed that the water extract was the most potential as anti-diabetic agent. Its blood glucose reducing capability of Rattus Norvegicus Rats Winstar strain was 56.37 % that was the higher than glibenclamide (49.59%) and the other extracts (ethyl acetate extract = 19.11% and methanol extract = 24.27%). The water extract was also safe to the body healthy of Mus Musculus Mice (20-30 g), Balb/c strain. The male mice oral administration of water extract at 2.6 mg/20g b.w. increased motoric activity, however female mice at 1.3 and 2.6 mg/20 g b.w., respectively oral administration experienced motoric activity increasing and retablishment capacity decreasing. The potency of Pluchea leaf water extract as anti-diabetic agent was predicted that there was cardiac glycoside compounds contribution to reduce blood glucose