Changes in Estimated Glomerular Filtration Rate Over Time in South African HIV-1-Infected Patients Receiving Tenofovir: a Retrospective Cohort Study

Tenofovir has been associated with decline in kidney function, but in patients with low baseline kidney function, improvements over time have been reported. Additionally, the magnitude and trajectory of estimated glomerular filtration rate (eGFR) changes may differ according to how eGFR is calculated. We described changes in eGFR over time, and the incidence of, and risk factors for, kidney toxicity, in a South African cohort