PURPOSE: Alveolar soft part sarcoma (ASPS) is a rare, chemoresistant soft tissue sarcoma. ASPS harbors the t(17-X) (p11.2;q25) translocation, resulting in the ASPACR1-TFE3 fusion protein, causing MET autophosphorylation and activation of downstream signaling. The tumor vascular pattern prompted us to use sunitinib malate (SM), a tyrosine kinase inhibitor with antiangiogenic properties. EXPERIMENTAL DESIGN: Since July 2007, five patients with progressive metastatic ASPS have been treated with continuous SM 37.5 mg/d on a named basis. Four patients are evaluable for response. In four cases, cryopreserved material was available. Upstream and downstream targets of receptor tyrosine kinase (RTK) pathways, as well as mechanisms of activation, wer...
STS represents a rare and highly diverse group of mesenchymal neoplasms, consisting of more than 50 ...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Contains fulltext : 170511.pdf (publisher's version ) (Closed access)Purpose: Uter...
Purpose: Alveolar soft part sarcoma (ASPS) is a rare, chemoresistant soft tissue sarcoma. ASPS harbo...
BACKGROUND: The purpose of this study was to confirm sunitinib activity in alveolar soft part sarcom...
Importance: Alveolar soft-part sarcoma (ASPS) is a rare, translocation-driven sarcoma of the soft ti...
Yitian Wang,* Li Min,* Yong Zhou, Fan Tang, Yi Luo, Wenli Zhang, Hong Duan, Chongqi TuDepartment of ...
Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma with a propensity for lung metastase...
PURPOSE OF REVIEW: We give an overview on the emerging compounds for patients with soft tissue sarco...
Soft tissue sarcomas (STS) are a rare, heterogeneous, and challenging group of cancers to treat effe...
Background: Alveolar soft part sarcoma (ASPS) is an orphan malignancy associated with a rearrangeme...
Alveolar soft part sarcoma (ASPS) is a rare malignant tumor that generally occurs in adolescents and...
Alveolar soft part sarcoma (ASPS) is an extremely rare metastatic soft tissue tumor with a poor prog...
Alveolar soft part sarcoma(ASPS) is an orphan malignancy associated with a rearrangement of transcri...
BACKGROUND: Alveolar Soft Part Sarcoma (ASPS) is a rare, slow-growing, but highly vascular soft tiss...
STS represents a rare and highly diverse group of mesenchymal neoplasms, consisting of more than 50 ...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Contains fulltext : 170511.pdf (publisher's version ) (Closed access)Purpose: Uter...
Purpose: Alveolar soft part sarcoma (ASPS) is a rare, chemoresistant soft tissue sarcoma. ASPS harbo...
BACKGROUND: The purpose of this study was to confirm sunitinib activity in alveolar soft part sarcom...
Importance: Alveolar soft-part sarcoma (ASPS) is a rare, translocation-driven sarcoma of the soft ti...
Yitian Wang,* Li Min,* Yong Zhou, Fan Tang, Yi Luo, Wenli Zhang, Hong Duan, Chongqi TuDepartment of ...
Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma with a propensity for lung metastase...
PURPOSE OF REVIEW: We give an overview on the emerging compounds for patients with soft tissue sarco...
Soft tissue sarcomas (STS) are a rare, heterogeneous, and challenging group of cancers to treat effe...
Background: Alveolar soft part sarcoma (ASPS) is an orphan malignancy associated with a rearrangeme...
Alveolar soft part sarcoma (ASPS) is a rare malignant tumor that generally occurs in adolescents and...
Alveolar soft part sarcoma (ASPS) is an extremely rare metastatic soft tissue tumor with a poor prog...
Alveolar soft part sarcoma(ASPS) is an orphan malignancy associated with a rearrangement of transcri...
BACKGROUND: Alveolar Soft Part Sarcoma (ASPS) is a rare, slow-growing, but highly vascular soft tiss...
STS represents a rare and highly diverse group of mesenchymal neoplasms, consisting of more than 50 ...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Contains fulltext : 170511.pdf (publisher's version ) (Closed access)Purpose: Uter...