Caries and Innate Immunity: DEFB1 Gene Polymorphisms and Caries Susceptibility in Genetic Isolates from North-Eastern Italy
- Navarra, Chiara O
- Robino, Antonietta
- Pirastu, Nicola
- Bevilacqua, Lorenzo
- Gasparini, Paolo
- Di Lenarda, Roberto
- Crovella, Sergio
DOIAbstract
The DEFB1 gene, encoding for the constitutively expressed human \u3b2-defensin 1 (hBD1) antimicrobial peptide is a potential candidate when studying genetic susceptibility to caries. DEFB1 genetic variations have been reported as contributing to hBD1 production impairment, leading to a greater susceptibility to be infected by oral pathogens, also leading to periodontitis
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