Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus
- Hanssen, Mark JW
- Hoeks, Joris
- Brans, Boudewijn
- van der Lans, Anouk AJJ
- Schaart, Gert
- van den Driessche, Jose J
- Jorgensen, Johanna A
- Boekschoten, Mark V
- Hesselink, Matthijs KC
- Havekes, Bas
- Kersten, Sander
- Mottaghy, Felix M
- Lichtenbelt, Wouter D van Marken
- Schrauwen, Patrick
Publication date
January 2015
DOIAbstract
Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 degrees C) increased peripheral insulin sensitivity by similar to 43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake
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