Interrupt-driven software is difficult to test and debug, especially when interrupts can be nested and subject to priorities. Interrupts can arrive at arbitrary times, leading to an exponential blow-up in the number of cases to consider. We present a new formal approach to verifying interrupt-driven software based on symbolic execution. The approach leverages recent advances in the encoding of the execution traces of interacting, concurrent threads. We assess the performance of our method on benchmarks drawn from embedded systems code and device drivers, and experimentally compare it to conventional approaches that use source-to-source transformations. Our results show that our method significantly outperforms these techniques. To the b...