Efficient access to 5-substituted thiazoles by a novel metallotropic rearrangement
- Zambon, Alfonso
- Borsato, Giuseppe
- Brussolo, Stefania
- Frascella, Pietrogiulio
- Lucchini, Vittorio
DOIAbstract
A novel rearrangement process involving the migration of trimethylstannanyl or trimethylsilanyl groups around the thiazole ring provides access to either 2- or 5-metallated thiazoles by tuning the reaction conditions. The proposed mechanism, based on experimental evidence, is characterized by the catalytic role of thiazole bisadducts as metal-transfer agents. \ua9 2007 Elsevier Ltd. All rights reserved
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