Background Nicotine dependence is maintained by neurobiological adaptations in the dopaminergic brain reward pathway with the contribution of opioidergic circuits. This study assessed the role of opioid peptides and receptors on the molecular changes associated with nicotine dependence. To this aim we analysed nicotine effects on opioid gene and receptor expression in the reward pathway in a nicotine sensitization model. Methods Sprague-Dawley rats received nicotine administrations for five days and locomotor activity assessment showed the development of sensitization. The mRNA expression of prodynorphin (pdyn), pronociceptin (pnoc) and the respective receptors was measured by quantitative PCR in the ventral midbrain (VM), the nucleus accum...
Delta opioid reseptörleri (DOR) ve DOR’un proenkefalin (PENK) prekürsöründen köken alan endojen liga...
Understanding effects of chronic nicotine requires identifying the neurons and synapses whose respon...
Abstract: Nicotine withdrawal causes somatic and negative affective symptoms that contribute to rela...
Background Nicotine dependence is maintained by neurobiological adaptations in the dopaminergic brai...
WOS: 000406298600002PubMed ID: 28509375Delta and kappa opioid receptors (DOR and KOR, respectively) ...
Nicotine is the primary component of tobacco that maintains the smoking habit and develops addiction...
It has been shown previously that the endogenous opioid system may be involved in the behavioral eff...
Multiple studies in animal models and humans suggest that the endogenous opioid system is an importa...
We investigated the behavioral and molecular interactions between cocaine and nicotine, through eval...
WOS: 000392790300013PubMed ID: 27890744Pro-opiomelanocortin (POMC)-derived peptides and their recept...
The endogenous opioid system plays an important role in the behavioral effects of nicotine. Thus, mi...
Tobacco use is one of the primary factors for global burden of disease and often results in life-lon...
Rationale. Nicotine displays rewarding and aversive effects, and while dopamine has been linked with...
Nicotine is the addictive component of tobacco smoke. It elicits its psychoactive effects by binding...
Pro-opiomelanokortin (POMC), endojen opioiderjik sistemi oluşturan en önemli peptid prekürsörlerinde...
Delta opioid reseptörleri (DOR) ve DOR’un proenkefalin (PENK) prekürsöründen köken alan endojen liga...
Understanding effects of chronic nicotine requires identifying the neurons and synapses whose respon...
Abstract: Nicotine withdrawal causes somatic and negative affective symptoms that contribute to rela...
Background Nicotine dependence is maintained by neurobiological adaptations in the dopaminergic brai...
WOS: 000406298600002PubMed ID: 28509375Delta and kappa opioid receptors (DOR and KOR, respectively) ...
Nicotine is the primary component of tobacco that maintains the smoking habit and develops addiction...
It has been shown previously that the endogenous opioid system may be involved in the behavioral eff...
Multiple studies in animal models and humans suggest that the endogenous opioid system is an importa...
We investigated the behavioral and molecular interactions between cocaine and nicotine, through eval...
WOS: 000392790300013PubMed ID: 27890744Pro-opiomelanocortin (POMC)-derived peptides and their recept...
The endogenous opioid system plays an important role in the behavioral effects of nicotine. Thus, mi...
Tobacco use is one of the primary factors for global burden of disease and often results in life-lon...
Rationale. Nicotine displays rewarding and aversive effects, and while dopamine has been linked with...
Nicotine is the addictive component of tobacco smoke. It elicits its psychoactive effects by binding...
Pro-opiomelanokortin (POMC), endojen opioiderjik sistemi oluşturan en önemli peptid prekürsörlerinde...
Delta opioid reseptörleri (DOR) ve DOR’un proenkefalin (PENK) prekürsöründen köken alan endojen liga...
Understanding effects of chronic nicotine requires identifying the neurons and synapses whose respon...
Abstract: Nicotine withdrawal causes somatic and negative affective symptoms that contribute to rela...