Recent studies about greenhouse gas (GHG) emissions show that sewer collection systems and wastewater treatment plants (WWTPs) are anthropogenic GHG potential sources. Therefore, they contribute to the climate change and air pollution. This increasing interest towards climate change has led to the development of new tools for WWTP design and management. This paper presents the first results of a research project aiming at setting-up an innovative mathematical model platform for the design and management of WWTPs. More specifically, the study presents the project’s strategy aimed at setting-up a plant-wide mathematical model which can be used as a tool for reducing/ controlling GHG from WWTP. Such tool is derived from real data and ...