Topics
pyrimidineChemical substance
tyrosineChemical substance
glioblastoma multiformeDisease
neuroblastomaDisease
kinaseProtein
The present invention refers to 4-amino-substituted pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine derivatives of formula I and IV able to target the Src family kinases (SFKs) such as Src, Fyn and Hck tyrosine kinases as well as Abl tyrosine kinase and uses and method of preparation thereof. In particular, the compounds of the invention are for use in the treatment and/or prevention of cancer, such as neuroblastoma (NB) or glioblastoma multiforme (GBM) or for use in the treatment and/or prevention of neurodegenerative diseases such as taupathie
This invention relates to pyrrolopyrimidine comprising compounds that may be useful as inhibitors of...
New 4-aminopyrazolo[3,4-d]pyrimidines bearing various substituents at the position 1 and 6, were syn...
The therapeutic use of tyrosine kinase inhibitors (TKIs) represents one of the successful strategies...
The present invention refers to 4-amino-substituted pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyr...
The present invention refers to 4-\u200bamino-\u200bsubstituted pyrazolo[3,\u200b4-\u200bd]\u200bpyr...
The present invention refers to 4-amino-substituted pyrazolo[3,4-d]pyrimidine derivatives, belonging...
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine are described. C...
4-\u200bAmino-\u200bsubstituted pyrazolo[3,\u200b4-\u200bd]\u200bpyrimidine and pyrrolo[2,\u200b3-\u...
Title compds. I [R1 = cyclopropylamino, NHPr, pyrrolidin-1-yl, NHBu, NEt2, morpholin-4-yl, NHCH2CH2O...
Novel 1,4,6-trisubstituted pyrazolo[3,4-d]pyrimidines are reported with preliminary in vitro activit...
The synthesis of new 4-amino substituted pyrazolo[3,4-d]pyrimidines along with their activity in cel...
This invention relates to pyrrolopyrimidine comprising compounds that may be useful as inhibitors of...
New 4-aminopyrazolo[3,4-d]pyrimidines bearing various substituents at the position 1 and 6, were syn...
The therapeutic use of tyrosine kinase inhibitors (TKIs) represents one of the successful strategies...
The present invention refers to 4-amino-substituted pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyr...
The present invention refers to 4-\u200bamino-\u200bsubstituted pyrazolo[3,\u200b4-\u200bd]\u200bpyr...
The present invention refers to 4-amino-substituted pyrazolo[3,4-d]pyrimidine derivatives, belonging...
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine are described. C...
4-\u200bAmino-\u200bsubstituted pyrazolo[3,\u200b4-\u200bd]\u200bpyrimidine and pyrrolo[2,\u200b3-\u...
Title compds. I [R1 = cyclopropylamino, NHPr, pyrrolidin-1-yl, NHBu, NEt2, morpholin-4-yl, NHCH2CH2O...
Novel 1,4,6-trisubstituted pyrazolo[3,4-d]pyrimidines are reported with preliminary in vitro activit...
The synthesis of new 4-amino substituted pyrazolo[3,4-d]pyrimidines along with their activity in cel...
This invention relates to pyrrolopyrimidine comprising compounds that may be useful as inhibitors of...
New 4-aminopyrazolo[3,4-d]pyrimidines bearing various substituents at the position 1 and 6, were syn...
The therapeutic use of tyrosine kinase inhibitors (TKIs) represents one of the successful strategies...
Add to ORKG