Inactivating mutations in the sphingosine-1-phosphate (S1P) receptor 2 (S1PR2) promoter have been associated with the germinal center (GC) B-cell diffuse large B-cell lymphoma (GCB-DLBCL) subtype. In this issue of Blood, Flori et al have now identified S1PR2 as a tumor suppressor that is transcriptionally silenced by forkhead box protein 1 (FOXP1) in the aggressive, activated B-cell (ABC-DLBCL) subtype.1
SummaryDiffuse large B cell lymphoma (DLBCL) is a heterogeneous disease composed of at least two dis...
FOXP1 (Forkhead box-P1) is a winged-helix transcription factor that is differentially expressed in r...
FOXP2 shares partially overlapping normal tissue expression and functionality with FOXP1; an establi...
Inactivating mutations in the sphingosine-1-phosphate (S1P) receptor 2 (S1PR2) promoter have been as...
Aberrant expression of the oncogenic transcription factor FOXP1 is a common feature of diffuse large...
Germinal centre B-cell-like diffuse large B-cell lymphoma (GCB-DLBCL) is a common malignancy, yet th...
The Epstein-Barr virus (EBV) is found almost exclusively in the activated B cell (ABC) subtype of di...
The Epstein-Barr virus (EBV) is found almost exclusively in the activated B-cell (ABC) subtype of di...
The sphingosine-1-phosphate receptor S1PR2 and its downstream signaling pathway is commonly silenced...
The FOXP1 (forkhead box P1) transcription factor is a marker of poor prognosis in diffuse large B-ce...
The FOXP1 forkhead transcription factor is targeted by recurrent chromosome translocations in severa...
STAT3 plays a crucial role in promoting progression of human cancers, including several types of B-c...
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of mature B-cell lymphoma. While th...
The transcription factor FOXP1 is prominently expressed in mature B cells and is a potential oncogen...
FOXP1 (Forkhead box-P1) is a winged-helix transcription factor that is differentially expressed in r...
SummaryDiffuse large B cell lymphoma (DLBCL) is a heterogeneous disease composed of at least two dis...
FOXP1 (Forkhead box-P1) is a winged-helix transcription factor that is differentially expressed in r...
FOXP2 shares partially overlapping normal tissue expression and functionality with FOXP1; an establi...
Inactivating mutations in the sphingosine-1-phosphate (S1P) receptor 2 (S1PR2) promoter have been as...
Aberrant expression of the oncogenic transcription factor FOXP1 is a common feature of diffuse large...
Germinal centre B-cell-like diffuse large B-cell lymphoma (GCB-DLBCL) is a common malignancy, yet th...
The Epstein-Barr virus (EBV) is found almost exclusively in the activated B cell (ABC) subtype of di...
The Epstein-Barr virus (EBV) is found almost exclusively in the activated B-cell (ABC) subtype of di...
The sphingosine-1-phosphate receptor S1PR2 and its downstream signaling pathway is commonly silenced...
The FOXP1 (forkhead box P1) transcription factor is a marker of poor prognosis in diffuse large B-ce...
The FOXP1 forkhead transcription factor is targeted by recurrent chromosome translocations in severa...
STAT3 plays a crucial role in promoting progression of human cancers, including several types of B-c...
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of mature B-cell lymphoma. While th...
The transcription factor FOXP1 is prominently expressed in mature B cells and is a potential oncogen...
FOXP1 (Forkhead box-P1) is a winged-helix transcription factor that is differentially expressed in r...
SummaryDiffuse large B cell lymphoma (DLBCL) is a heterogeneous disease composed of at least two dis...
FOXP1 (Forkhead box-P1) is a winged-helix transcription factor that is differentially expressed in r...
FOXP2 shares partially overlapping normal tissue expression and functionality with FOXP1; an establi...
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