MET tyrosine kinase receptor expression and amplification as prognostic biomarkers of survival in gastroesophageal adenocarcinoma
- Catenacci, Daniel V. T
- Ang, Agnes
- Liao, Wei Li
- Shen, Jing
- O'Day, Emily
- Loberg, Robert D
- Cecchi, Fabiola
- Hembrough, Todd
- RUZZO, ANNAMARIA
- Graziano, Francesco
DOIAbstract
MET gene amplification and Met protein overexpression may be associated with a poor prognosis. The MET/Met status is typically determined with fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC), respectively. Targeted proteomics uses mass spectrometry-based selected reaction monitoring (SRM) to accurately quantitate Met expression. FISH, IHC, and SRM analyses were compared to characterize the prognostic value of MET/Met in gastroesophageal adenocarcinoma (GEC)
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