Inherited germline mutations in the tumour suppressor gene BRCA1 (BReast CAncer susceptibility gene 1) can lead to an increased risk for various cancers. Evidence now suggests that epigenetic changes resulting in reduced or absent expression of BRCA1 are also important causative factors. BRCA1 has many known roles, such as DNA damage repair, cell cycle control and regulation of transcription. In addition, a recent study has identified yet another function for BRCA1: to protect cells from oxidative stress, a contributory factor in the development of many cancers, including breast cancer. BRCA1 is known to stimulate Nrf2, a transcription factor that regulates the expression of phase II enzymes, which are important in the detoxification of che...
AbstractInherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers. Thei...
PhD ThesisThe aim of this study was to elucidate the underlying molecular genetic mechanisms of radi...
The breast tumor kinase (Brk) is over-expressed in 80% of all breast cancers and we sought to determ...
Background: DNA repair pathways, cell cycle arrest checkpoints, and cell death induction are present...
Germline mutations to BRCA1 account for approximately 30% of familial breast cancer, with carriers h...
It has previously been demonstrated that peripheral blood lymphocytes of healthy women carrying BRCA...
Transcriptional and functional regulation of the breast cancer susceptibility gene 1 (BRCA1) in the ...
ABSTRACT Individuals that carry deleterious mutations in the breast and ovarian cancer susceptibilit...
Background: Breast cancer risk increases drastically in individuals carrying a germline BRCA1 mutati...
Purpose: Up to 90% of hereditary breast cancer cases are linked to germ-line mutations in one of the...
BRCA1 is a well-known breast cancer risk gene, involved in DNA damage repair via homologous recombin...
Purpose: The dose intensity of radiotherapy (RT) used in cancer treatment is limited in rare individ...
PARP inhibitors can be used to induce synthetic lethality in cells with bi-allelic BRCA1 and BRCA2 m...
DNA repair mechanisms in cells maintain genomic stability and prevent cancer. DNA repair defects can...
Background: Germ-line mutations of the breast cancer susceptibility gene-1 (BRCA1) increase the susc...
AbstractInherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers. Thei...
PhD ThesisThe aim of this study was to elucidate the underlying molecular genetic mechanisms of radi...
The breast tumor kinase (Brk) is over-expressed in 80% of all breast cancers and we sought to determ...
Background: DNA repair pathways, cell cycle arrest checkpoints, and cell death induction are present...
Germline mutations to BRCA1 account for approximately 30% of familial breast cancer, with carriers h...
It has previously been demonstrated that peripheral blood lymphocytes of healthy women carrying BRCA...
Transcriptional and functional regulation of the breast cancer susceptibility gene 1 (BRCA1) in the ...
ABSTRACT Individuals that carry deleterious mutations in the breast and ovarian cancer susceptibilit...
Background: Breast cancer risk increases drastically in individuals carrying a germline BRCA1 mutati...
Purpose: Up to 90% of hereditary breast cancer cases are linked to germ-line mutations in one of the...
BRCA1 is a well-known breast cancer risk gene, involved in DNA damage repair via homologous recombin...
Purpose: The dose intensity of radiotherapy (RT) used in cancer treatment is limited in rare individ...
PARP inhibitors can be used to induce synthetic lethality in cells with bi-allelic BRCA1 and BRCA2 m...
DNA repair mechanisms in cells maintain genomic stability and prevent cancer. DNA repair defects can...
Background: Germ-line mutations of the breast cancer susceptibility gene-1 (BRCA1) increase the susc...
AbstractInherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers. Thei...
PhD ThesisThe aim of this study was to elucidate the underlying molecular genetic mechanisms of radi...
The breast tumor kinase (Brk) is over-expressed in 80% of all breast cancers and we sought to determ...