Ustekinumab is a fully human monoclonal antibody, generated via molecular engineering from transgenic mice, genetically modified so they cannot produce murine antibodies, but only human antibodies. Ustekinumab binds in a selective manner to the p40 subunit which contributes to the structure of both IL-12 (p35/p40) and IL-23 (p19/p40), which play a key role in the pathogenesis of immune-mediated inflammatory diseases (IMIDs)
Crohn’s disease is an immune-mediated disease that results in panenteric chronic inflammation in gen...
As our comprehension of the pathogenic mechanisms of inflammatory bowel disease (IBD) increases, the...
Aranzazu Jauregui-Amezaga, Michael Somers, Heiko De Schepper, Elisabeth Macken Depart...
Ustekinumab is a subcutaneously and intravenously administered fully human monoclonal immunoglobulin...
Interleukin-12 (IL-12) and interleukin-23(IL-23) are cytokines that have been shown to have a role ...
Ustekinumab is an antagonistic human monoclonal immunoglobulin G1 antibody that targets p40, a commo...
Aim. To review data on the efficiency and safety of using Ustekinumab in patients with Crohn’s disea...
Psoriasis is a chronic relapsing immunoinflammatory dermatosis that is commonly associated with syst...
The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–mediated responses ...
Ustekinumab is a fully human IgG1κ monoclonal antibody targeting interleukin (IL)-12/23 p40 subunit....
<div><p>Ustekinumab is a fully human IgG1κ monoclonal antibody targeting interleukin (IL)-12/23 p40 ...
In patients with Crohn's disease, the efficacy of ustekinumab, a human monoclonal antibody against i...
Parakkal Deepak, Edward V Loftus Jr Division of Gastroenterology and Hepatology, Mayo Clinic College...
Inhibitors of interleukin-12/23 (IL-12/23) are compounds which bind to both IL-12 and IL-23 and inac...
Crohn’s disease is an immune-mediated disease that results in panenteric chronic inflammation in gen...
Crohn’s disease is an immune-mediated disease that results in panenteric chronic inflammation in gen...
As our comprehension of the pathogenic mechanisms of inflammatory bowel disease (IBD) increases, the...
Aranzazu Jauregui-Amezaga, Michael Somers, Heiko De Schepper, Elisabeth Macken Depart...
Ustekinumab is a subcutaneously and intravenously administered fully human monoclonal immunoglobulin...
Interleukin-12 (IL-12) and interleukin-23(IL-23) are cytokines that have been shown to have a role ...
Ustekinumab is an antagonistic human monoclonal immunoglobulin G1 antibody that targets p40, a commo...
Aim. To review data on the efficiency and safety of using Ustekinumab in patients with Crohn’s disea...
Psoriasis is a chronic relapsing immunoinflammatory dermatosis that is commonly associated with syst...
The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–mediated responses ...
Ustekinumab is a fully human IgG1κ monoclonal antibody targeting interleukin (IL)-12/23 p40 subunit....
<div><p>Ustekinumab is a fully human IgG1κ monoclonal antibody targeting interleukin (IL)-12/23 p40 ...
In patients with Crohn's disease, the efficacy of ustekinumab, a human monoclonal antibody against i...
Parakkal Deepak, Edward V Loftus Jr Division of Gastroenterology and Hepatology, Mayo Clinic College...
Inhibitors of interleukin-12/23 (IL-12/23) are compounds which bind to both IL-12 and IL-23 and inac...
Crohn’s disease is an immune-mediated disease that results in panenteric chronic inflammation in gen...
Crohn’s disease is an immune-mediated disease that results in panenteric chronic inflammation in gen...
As our comprehension of the pathogenic mechanisms of inflammatory bowel disease (IBD) increases, the...
Aranzazu Jauregui-Amezaga, Michael Somers, Heiko De Schepper, Elisabeth Macken Depart...