Synthesis of Mesoionic Isoquinolines by Rhodium(III)â Catalyzed Câ H Activation

Hydroxylâ substituted benzaldimines underwent a RhIIIâ catalyzed Câ H activation and annulation with alkynes to provide novel mesoionic isoquinoline derivatives in moderate to excellent yields using oxygen as an internal anion source. This simple and efficient approach has a broad substrate scope.Novel mesoionic salts: Hydroxylâ substituted benzaldimines underwent a RhIIIâ catalyzed Câ H activation and annulation with alkynes to provide novel mesoionic isoquinoline derivatives in moderate to excellent yields using oxygen as an internal anion source (see scheme; TsOH=pâ toluenesulfonic acid).Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137320/1/chem201504245-sup-0001-misc_information.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137320/2/chem201504245.pd