Retinal macrophages synthesize C3 and activate complement in AMD and in models of focal retinal degeneration
- Natoli, Riccardo
- Fernando, Nilisha
- Jiao, Haihan
- Racic, Tanja
- Madigan, Michele
- Barnett, Nigel L.
- Chu-Tan, Joshua A.
- Valter, Krisztina
- Provis, Jan
- Rutar, Matt
Publication date
June 2017
DOI Publisher
Association for Research in Vision and Ophthalmology (ARVO) ISSN
1552-5783 Citation count (estimate)
4Abstract
PURPOSE. Complement system dysregulation is strongly linked to the progression of age-related macular degeneration (AMD). Deposition of complement including C3 within the lesions in atrophic AMD is thought to contribute to lesion growth, although the contribution of local cellular sources remains unclear. We investigated the role of retinal microglia and macrophages in complement activation within atrophic lesions, in AMD and in models of focal retinal degeneration
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