Total Synthesis of (±)-Welwitindolinone A Isonitrile

Reisman, Sarah E.
Ready, Joseph M.
Hasuoka, Atsushi
Smith, Catherine J.
Wood, John L.

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Publication date

February 2006

DOI

10.1021/ja057640s

Publisher

American Chemical Society (ACS)

ISSN

0002-7863

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Abstract

A highly stereoselective total synthesis of the alkaloid natural product welwitindolinone A isonitrile has been completed. The synthesis utilizes a chloronium ion mediated semi-pinacol rearrangement to simultaneously install the C10 quaternary center and neopentyl chlorine and a novel anionic cyclization to construct the spiro-oxindole with complete stereocontrol

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Total Synthesis of (±)-Welwitindolinone A Isonitrile

Abstract

Extracted data

Total Synthesis of (±)-Welwitindolinone A Isonitrile

Abstract

Extracted data

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