Studies of amplification and/or overexpression of c-myc, HER-2/neu, and H-ras in breast cancer have shown that each is associated with a poor prognosis. The purpose of this study was to explore the possibility that there is a preferred sequence of amplification of these oncogenes in breast cancer. The frequencies of amplification and patterns of co-amplification of c-myc, HER-2/neu, and H-ras were studied in a group of 84 breast cancers. The data suggested a preferred sequence of amplification that consisted of c-myc amplification-HER-2/neu amplification-H-ras amplification. This model was supported by loglinear analysis. In addition, the levels of amplification of JC-A, a DNA fragment newly isolated from a patient with advanced breast canc...
At present, the biology of breast cancer remains poorly understood. Currently, lymph node metastases...
Background: Amplification of HER2 is seen in 20-30% of breast cancer cases. Measurement of HER2 gene...
Cancer is a genetic disease. Breast cancer tumorigenesis can be described as a multi-step process in...
Studies of amplification and/or overexpression of c-myc, HER-2/neu, and H-ras in breast cancer have ...
The c-myc proto-oncogene was analyzed in 311 cases of primary breast cancer, in 8% of which it was f...
We have analyzed genomic DNA sequences from 125 prospectively collected single unilateral primary br...
In breast cancer, amplification of MYC is consistently observed in aggressive forms of disease and c...
The predictive and prognostic implication of oncogene amplification in breast cancer has received g...
One in nine women in Canada will develop breast cancer during their lifetime. Generally, breast canc...
In a separate study (F. Courjal et al., Cancer Res., 57: 4360-4367, 1997), we have analyzed by South...
DNA amplification is frequent in breast cancer and has been associated with specific clinicopatholog...
HER-2/neu protooncogene amplification and protein expression were analyzed with slot blot and Wester...
Breast cancer is one of the most common cancers in women. The incidence of breast cancer in 2014 in ...
Chromosomal structural variations play an important role in determining the transcriptional landscap...
BACKGROUND: Oncogene amplification and overexpression occur in tumor cells. Amplification status may...
At present, the biology of breast cancer remains poorly understood. Currently, lymph node metastases...
Background: Amplification of HER2 is seen in 20-30% of breast cancer cases. Measurement of HER2 gene...
Cancer is a genetic disease. Breast cancer tumorigenesis can be described as a multi-step process in...
Studies of amplification and/or overexpression of c-myc, HER-2/neu, and H-ras in breast cancer have ...
The c-myc proto-oncogene was analyzed in 311 cases of primary breast cancer, in 8% of which it was f...
We have analyzed genomic DNA sequences from 125 prospectively collected single unilateral primary br...
In breast cancer, amplification of MYC is consistently observed in aggressive forms of disease and c...
The predictive and prognostic implication of oncogene amplification in breast cancer has received g...
One in nine women in Canada will develop breast cancer during their lifetime. Generally, breast canc...
In a separate study (F. Courjal et al., Cancer Res., 57: 4360-4367, 1997), we have analyzed by South...
DNA amplification is frequent in breast cancer and has been associated with specific clinicopatholog...
HER-2/neu protooncogene amplification and protein expression were analyzed with slot blot and Wester...
Breast cancer is one of the most common cancers in women. The incidence of breast cancer in 2014 in ...
Chromosomal structural variations play an important role in determining the transcriptional landscap...
BACKGROUND: Oncogene amplification and overexpression occur in tumor cells. Amplification status may...
At present, the biology of breast cancer remains poorly understood. Currently, lymph node metastases...
Background: Amplification of HER2 is seen in 20-30% of breast cancer cases. Measurement of HER2 gene...
Cancer is a genetic disease. Breast cancer tumorigenesis can be described as a multi-step process in...