HIV-specific CD4+ T helper lymphocytes are preferred targets for infection. Although complete interruption of combination antiretroviral therapy (ART) can form part of therapeutic manipulations, there is grave concern that the resumption of viral replication might destroy, perhaps irreversibly, these T helper populations. High viremia blocks the proliferation capacity of HIV-specific helper cells. However, cytokine production assays imply that some antigen-specific effector function is retained. Despite this careful work, it remains unclear whether the return of HIV-1 replication physically destroys HIV-1–specific T helper cells in the peripheral blood. Difficulties in producing stable peptide-MHC class II complexes and the very low frequen...
Despite its potent antiviral activity, highly active antiretroviral therapy (HAART) only exerts a ma...
ObjectiveTo study the contribution of γδ T cells to the persistent HIV reservoir.DesignFifteen HIV-s...
SummaryHighly active antiretroviral therapy (HAART) suppresses HIV-1 replication but cannot eliminat...
HIV-specific CD4+ T helper lymphocytes are preferred targets for infection. Although complete interr...
Potent combinations of antiretroviral drugs diminish the turnover of CD4+ T lymphocytes productively...
CD4(+) T cells are thought to be critical in the maintenance of virus-specific CD8(+) cytotoxic T-ce...
HIV-1-specific CD8+ T cells are an important component of HIV-1 curative strategies. Viral variants ...
Cytotoxic T lymphocytes (CTLs) play a central role in the control of persistent HIV infection in hum...
Human immunodeficiency virus type 1 (HIV-1)-infected subjects treated early after infection have pre...
Objectives: Antiretroviral therapy (ART) suppresses HIV viraemia, thereby reducing the antigenic dri...
Background: The clinical significance and cellular sources of residual human immunodeficiency virus ...
Therapeutic suppression of human immunodeficiency virus type 1 (HIV-1) replication may help elucidat...
OBJECTIVES: Antiretroviral therapy (ART) suppresses HIV viraemia, thereby reducing the antigenic dri...
OBJECTIVES: Antiretroviral therapy (ART) suppresses HIV viraemia, thereby reducing the antigenic dri...
Elite controllers suppress human immunodeficiency virus (HIV) viremia to below the limit of detectio...
Despite its potent antiviral activity, highly active antiretroviral therapy (HAART) only exerts a ma...
ObjectiveTo study the contribution of γδ T cells to the persistent HIV reservoir.DesignFifteen HIV-s...
SummaryHighly active antiretroviral therapy (HAART) suppresses HIV-1 replication but cannot eliminat...
HIV-specific CD4+ T helper lymphocytes are preferred targets for infection. Although complete interr...
Potent combinations of antiretroviral drugs diminish the turnover of CD4+ T lymphocytes productively...
CD4(+) T cells are thought to be critical in the maintenance of virus-specific CD8(+) cytotoxic T-ce...
HIV-1-specific CD8+ T cells are an important component of HIV-1 curative strategies. Viral variants ...
Cytotoxic T lymphocytes (CTLs) play a central role in the control of persistent HIV infection in hum...
Human immunodeficiency virus type 1 (HIV-1)-infected subjects treated early after infection have pre...
Objectives: Antiretroviral therapy (ART) suppresses HIV viraemia, thereby reducing the antigenic dri...
Background: The clinical significance and cellular sources of residual human immunodeficiency virus ...
Therapeutic suppression of human immunodeficiency virus type 1 (HIV-1) replication may help elucidat...
OBJECTIVES: Antiretroviral therapy (ART) suppresses HIV viraemia, thereby reducing the antigenic dri...
OBJECTIVES: Antiretroviral therapy (ART) suppresses HIV viraemia, thereby reducing the antigenic dri...
Elite controllers suppress human immunodeficiency virus (HIV) viremia to below the limit of detectio...
Despite its potent antiviral activity, highly active antiretroviral therapy (HAART) only exerts a ma...
ObjectiveTo study the contribution of γδ T cells to the persistent HIV reservoir.DesignFifteen HIV-s...
SummaryHighly active antiretroviral therapy (HAART) suppresses HIV-1 replication but cannot eliminat...