Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
- Berndt, Sonja I.
- Camp, Nicola J.
- Skibola, Christine F.
- Vijai, Joseph
- Wang, Zhaoming
- Gu, Jian
- Nieters, Alexandra
- Kelly, Rachel S.
- Smedby, Karin E.
- Monnereau, Alain
- Cozen, Wendy
- Cox, Angela
- Wang, Sophia S.
- Lan, Qing
- Teras, Lauren R.
- Ma, Moara
- Ye, Meredith
- Brooks-Wilson, Angela R.
- Hartge, Patricia
- Ma, Mark
- Birmann, Brenda M.
- Vajdic, Claire M.
- Cocco, Pierluigi
- Zhang, Yawei
- Giles, Graham G.
- Zeleniuch-Jacquotte, Anne
- Lawrence, Charles
- Montalvan, Rebecca
- Burdett, Laurie
- Hutchinson, Amy
- Ye, Yuanqing
- Call, Timothy G.
- Shanafelt, Tait D.
- Novak, Anne
- Kay, Neil E.
- Cunningham, Julie M.
- Allmer, Cristine
- Hjalgrim, Henrik
- Adami, Hans-Olov
- Ma, Mads
- Glimelius, Bengt
- Chang, Ellen T.
- Ma, Martha
- Curtin, Karen
- Cannon-Albright, Lisa A.
- Diver, W Ryan
- Link, Brian K.
- Weiner, George J.
- Conde, Lucia
- Bracci, Paige M.
- Riby, Jacques
- Arnett, Donna K.
- Zhi, Degui
- Leach, Justin M.
- Holly, Elizabeth A.
- Jackson, Rebecca D.
- Tinker, Lesley F.
- Benavente, Yolanda
- Sala, Núria
- Casabonne, Delphine
- Becker, Nikolaus
- Boffetta, Paolo
- Brennan, Paul
- Foretova, Lenka
- Maynadié, Marc
- Mckay, James
- Staines, Anthony
- Chaffee, Kari G.
- Achenbach, Sara J.
- Vachon, Celine M.
- Goldin, Lynn R.
- Strom, Sara S.
- Leis, Jose F.
- Weinberg, J. Brice
- Caporaso, Neil E.
- Norman, Aaron D.
- de Roos, Anne
- Morton, Lindsay M.
- Severson, Richard K.
- Riboli, Elio
- Vineis, Paolo
- Kaaks, Rudolph
- Ma, Giovanna
- Weiderpass, Elisabete
- Ma, María- Dolores
- Vermeulen, Roel C. H.
- Travis, Ruth C.
- Southey, Melissa C.
- Milne, Roger L.
- Albanes, Demetrius
- Virtamo, Jarmo
- Weinstein, Stephanie
- Clavel, Jacqueline
- Zheng, Tongzhang
- Holford, Theodore R.
- Villano, Danylo J.
- Ma, Ann
- Spinelli, John J.
- Gascoyne, Randy D.
- Connors, Joseph M.
- Bertrand, Kimberly A.
- Giovannucci, Edward
- Kraft, Peter
- Kricker, Anne
- Turner, Jenny
- Ma, Maria Grazia
- Ferri, Giovanni M.
- Miligi, Lucia
- Liang, Liming
- Ma, Baoshan
- Huang, Jinyan
- Crouch, Simon
- Park, Ju-Hyun
- Chatterjee, Nilanjan
- North, Kari E.
- Snowden, John A.
- Wright, Josh
- Fraumeni, Joseph F.
- Offit, Kenneth
- Wu, Xifeng
- de Sanjose, Silvia
- Cerhan, James R.
- Chanock, Stephen J.
- Rothman, Nathaniel
- Slager, Susan L.
DOIAbstract
International audienceChronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P = 2.55 x 10(-11)), 6p25.2 (rs73718779, SERPINB6, P = 1.97 x 10(-8)) and 3q28 (rs9815073, LPP, P = 3.62 x 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P = 1.00 x 10(-11)) in the combined analysis. We find suggestive evidence (P<5 x 10(-7)) for two ...
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