Cellular subtype expression and activation of CaMKII regulate the fate of atherosclerotic plaque
- MAIONE, SERENA
- CIPOLLETTA, ERSILIA
- Sorriento, Daniela
- Borriello, Francesco
- Soprano, Maria
- RUSCIANO, MARIA ROSARIA
- D'Esposito, Vittoria
- Markabaoui, Abdul Karim
- De Palma, Giovanni Domenico
- Martino, Giovanni
- Maresca, Lucio
- Nobile, Giuseppe
- CAMPIGLIA, Pietro
- Formisano, Pietro
- CICCARELLI, Michele
- Marone, Gianni
- Trimarco, Bruno
- IACCARINO, Guido
- ILLARIO , Maddalena
Publication date
January 2017
DOI ISSN
0021-9150 Citation count (estimate)
2Abstract
Atherosclerosis is a degenerative process of the arterial wall implicating activation of macrophages and proliferation of vascular smooth muscle cells. Calcium-calmodulin dependent kinase type II (CaMKII) in vascular smooth muscle cells (VSMCs) regulates proliferation, while in macrophages, this kinase governs diapedesis, infiltration and release of extracellular matrix enzymes. We aimed at understanding the possible role of CaMKII in atherosclerosis plaques to regulate plaque evolution towards stability or instability
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