One quarter of randomized clinical trials (RCTs) are prematurely discontinued and frequently remain unpublished. Trial registries can document whether a trial is ongoing, suspended, discontinued, or completed and therefore represent an important source for trial status information. The accuracy of this information is unclear. To examine the accuracy of completion status and reasons for discontinuation documented in trial registries as compared to corresponding publications of discontinued RCTs and to investigate potential predictors for accurate trial status information in registries. We conducted a cross-sectional study comparing information provided in publications (reference standard) to corresponding registry entries. First, we reviewed...
Premature discontinuation of clinical studies affects about 25% of randomised controlled trials (RCT...
To investigate the prevalence of discontinuation and nonpublication of surgical versus medical rando...
Premature discontinuation of clinical studies affects about 25% of randomised controlled trials (RCT...
Background One quarter of randomized clinical trials (RCTs) are prematurely discontinued and frequen...
Background We previously found that 25% of 1,017 randomized clinical trials (RCTs) approved between ...
BackgroundWe previously found that 25% of 1,017 randomized clinical trials (RCTs) approved between 2...
Objective: Trial registries were set up to improve transparency, remove duplication, improve awarene...
IMPORTANCE The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and oft...
IMPORTANCE The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and o...
To investigate the frequency of interim analyses, stopping rules, and data safety and monitoring boa...
Randomized controlled trials (RCTs) may be discontinued because of apparent harm, benefit, or futili...
BACKGROUND We previously found that 25% of 1,017 randomized clinical trials (RCTs) approved betwe...
OBJECTIVES: To investigate the frequency of interim analyses, stopping rules, and data safety and mo...
Abstract Background Randomized controlled trials (RCTs) may be discontinued because of apparent harm...
Artículo de publicación ISIIMPORTANCE The discontinuation of randomized clinical trials (RCTs) raise...
Premature discontinuation of clinical studies affects about 25% of randomised controlled trials (RCT...
To investigate the prevalence of discontinuation and nonpublication of surgical versus medical rando...
Premature discontinuation of clinical studies affects about 25% of randomised controlled trials (RCT...
Background One quarter of randomized clinical trials (RCTs) are prematurely discontinued and frequen...
Background We previously found that 25% of 1,017 randomized clinical trials (RCTs) approved between ...
BackgroundWe previously found that 25% of 1,017 randomized clinical trials (RCTs) approved between 2...
Objective: Trial registries were set up to improve transparency, remove duplication, improve awarene...
IMPORTANCE The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and oft...
IMPORTANCE The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and o...
To investigate the frequency of interim analyses, stopping rules, and data safety and monitoring boa...
Randomized controlled trials (RCTs) may be discontinued because of apparent harm, benefit, or futili...
BACKGROUND We previously found that 25% of 1,017 randomized clinical trials (RCTs) approved betwe...
OBJECTIVES: To investigate the frequency of interim analyses, stopping rules, and data safety and mo...
Abstract Background Randomized controlled trials (RCTs) may be discontinued because of apparent harm...
Artículo de publicación ISIIMPORTANCE The discontinuation of randomized clinical trials (RCTs) raise...
Premature discontinuation of clinical studies affects about 25% of randomised controlled trials (RCT...
To investigate the prevalence of discontinuation and nonpublication of surgical versus medical rando...
Premature discontinuation of clinical studies affects about 25% of randomised controlled trials (RCT...