Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
- Justice, A.E.
- Winkler, T.W.
- Feitosa, M.F.
- Graff, M.
- Fisher, V.A.
- Young, K.
- Barata, L.
- Deng, X.
- Czajkowski, J.
- Hadley, D.
- Ngwa, J.S.
- Ahluwalia, T.S.
- Chu, A.Y.
- Heard-Costa, N.L.
- Lim, E.
- Perez, J.
- Eicher, J.D.
- Kutalik, Z.
- Xue, L.
- Mahajan, A.
- Renström, F.
- Wu, J.
- Qi, Q.
- Ahmad, S.
- Alfred, T.
- Amin, N.
- Bielak, L.F.
- Bonnefond, A.
- Bragg, J.
- Cadby, G.
- Chittani, M.
- Coggeshall, S.
- Corre, T.
- Direk, N.
- Eriksson, J.
- Fischer, K.
- Gorski, M.
- Neergaard Harder, M.
- Horikoshi, M.
- Huang, T.
- Huffman, J.E.
- Jackson, A.U.
- Justesen, J.M.
- Kanoni, S.
- Kinnunen, L.
- Kleber, M.E.
- Komulainen, P.
- Kumari, M.
- Lim, U.
- Luan, J.
- Lyytikäinen, L.P.
- Mangino, M.
- Manichaikul, A.
- Marten, J.
- Middelberg, RPS
- Müller-Nurasyid, M.
- Navarro, P.
- Pérusse, L.
- Pervjakova, N.
- Sarti, C.
- Smith, A.V.
- Smith, J.A.
- Stančáková, A.
- Strawbridge, R.J.
- Stringham, H.M.
- Sung, Y.J.
- Tanaka, T.
- Teumer, A.
- Trompet, S.
- van der Laan, S.W.
- van der Most, P.J.
- Van Vliet-Ostaptchouk, J.V.
- Vedantam, S.L.
- Verweij, N.
- Vink, J.M.
- Vitart, V.
- Wu, Y.
- Yengo, L.
- Zhang, W.
- Hua Zhao, J.
- Zimmermann, M.E.
- Zubair, N.
- Abecasis, G.R.
- Adair, L.S.
- Afaq, S.
- Afzal, U.
- Bakker, SJL
- Bartz, T.M.
- Beilby, J.
- Bergman, R.N.
- Bergmann, S.
- Biffar, R.
- Blangero, J.
- Boerwinkle, E.
- Bonnycastle, L.L.
- Bottinger, E.
- Braga, D.
- Buckley, B.M.
- Buyske, S.
- Campbell, H.
- Chambers, J.C.
- Collins, F.S.
- Curran, J.E.
- de Borst, G.J.
- de Craen, AJM
- de Geus, EJC
- Dedoussis, G.
- Delgado, G.E.
- den Ruijter, H.M.
- Eiriksdottir, G.
- Eriksson, A.L.
- Esko, T.
- Faul, J.D.
- Ford, I.
- Forrester, T.
- Gertow, K.
- Gigante, B.
- Glorioso, N.
- Gong, J.
- Grallert, H.
- Grammer, T.B.
- Grarup, N.
- Haitjema, S.
- Hallmans, G.
- Hamsten, A.
- Hansen, T.
- Harris, T.B.
- Hartman, C.A.
- Hassinen, M.
- Hastie, N.D.
- Heath, A.C.
- Hernandez, D.
- Hindorff, L.
- Hocking, L.J.
- Hollensted, M.
- Holmen, O.L.
- Homuth, G.
- Jan Hottenga, J.
- Huang, J.
- Hung, J.
- Hutri-Kähönen, N.
- Ingelsson, E.
- James, A.L.
- Jansson, J.O.
- Jarvelin, M.R.
- Jhun, M.A.
- Jørgensen, M.E.
- Juonala, M.
- Kähönen, M.
- Karlsson, M.
- Koistinen, H.A.
- Kolcic, I.
- Kolovou, G.
- Kooperberg, C.
- Krämer, B.K.
- Kuusisto, J.
- Kvaløy, K.
- Lakka, T.A.
- Langenberg, C.
- Launer, L.J.
- Leander, K.
- Lee, N.R.
- Lind, L.
- Lindgren, C.M.
- Linneberg, A.
- Lobbens, S.
- Loh, M.
- Lorentzon, M.
- Luben, R.
- Lubke, G.
- Ludolph-Donislawski, A.
- Lupoli, S.
- Madden, PAF
- Männikkö, R.
- Marques-Vidal, P.
- Martin, N.G.
- McKenzie, C.A.
- McKnight, B.
- Mellström, D.
- Menni, C.
- Montgomery, G.W.
- Musk, A.B.
- Narisu, N.
- Nauck, M.
- Nolte, I.M.
- Oldehinkel, A.J.
- Olden, M.
- Ong, K.K.
- Padmanabhan, S.
- Peyser, P.A.
- Pisinger, C.
- Porteous, D.J.
- Raitakari, O.T.
- Rankinen, T.
- Rao, D.C.
- Rasmussen-Torvik, L.J.
- Rawal, R.
- Rice, T.
- Ridker, P.M.
- Rose, L.M.
- Bien, S.A.
- Rudan, I.
- Sanna, S.
- Sarzynski, M.A.
- Sattar, N.
- Savonen, K.
- Schlessinger, D.
- Scholtens, S.
- Schurmann, C.
- Scott, R.A.
- Sennblad, B.
- Siemelink, M.A.
- Silbernagel, G.
- Slagboom, P.E.
- Snieder, H.
- Staessen, J.A.
- Stott, D.J.
- Swertz, M.A.
- Swift, A.J.
- Taylor, K.D.
- Tayo, B.O.
- Thorand, B.
- Thuillier, D.
- Tuomilehto, J.
- Uitterlinden, A.G.
- Vandenput, L.
- Vohl, M.C.
- Völzke, H.
- Vonk, J.M.
- Waeber, G.
- Waldenberger, M.
- Westendorp, RGJ
- Wild, S.
- Willemsen, G.
- Wolffenbuttel, BHR
- Wong, A.
- Wright, A.F.
- Zhao, W.
- Zillikens, M.C.
- Baldassarre, D.
- Balkau, B.
- Bandinelli, S.
- Böger, C.A.
- Boomsma, D.I.
- Bouchard, C.
- Bruinenberg, M.
- Chasman, D.I.
- Chen, Y.D.
- Chines, P.S.
- Cooper, R.S.
- Cucca, F.
- Cusi, D.
- Faire, U.
- Ferrucci, L.
- Franks, P.W.
- Froguel, P.
- Gordon-Larsen, P.
- Grabe, H.J.
- Gudnason, V.
- Haiman, C.A.
- Hayward, C.
- Hveem, K.
- Johnson, A.D.
- Wouter Jukema, J.
- Kardia, SLR
- Kivimaki, M.
- Kooner, J.S.
- Kuh, D.
- Laakso, M.
- Lehtimäki, T.
- Marchand, L.L.
- März, W.
- McCarthy, M.I.
- Metspalu, A.
- Morris, A.P.
- Ohlsson, C.
- Palmer, L.J.
- Pasterkamp, G.
- Pedersen, O.
- Peters, A.
- Peters, U.
- Polasek, O.
- Psaty, B.M.
- Qi, L.
- Rauramaa, R.
- Smith, B.H.
- Sørensen, TIA
- Strauch, K.
- Tiemeier, H.
- Tremoli, E.
- van der Harst, P.
- Vestergaard, H.
- Vollenweider, P.
- Wareham, N.J.
- Weir, D.R.
- Whitfield, J.B.
- Wilson, J.F.
- Tyrrell, J.
- Frayling, T.M.
- Barroso, I.
- Boehnke, M.
- Deloukas, P.
- Fox, C.S.
- Hirschhorn, J.N.
- Hunter, D.J.
- Spector, T.D.
- Strachan, D.P.
- van Duijn, C.M.
- Heid, I.M.
- Mohlke, K.L.
- Marchini, J.
- Loos, RJF
- Kilpeläinen, T.O.
- Liu, C.T.
- Borecki, I.B.
- North, K.E.
- Cupples, L.A.
Publication date
April 2017
DOIAbstract
Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highligh...
Add to ORKG