Managing lethal cardiac arrhythmias is one of the biggest challenges in modern cardiology, and hence it is very important to understand the factors underlying such arrhythmias. While early afterdepolarizations (EAD) of cardiac cells is known to be one such arrhythmogenic factor, the mechanisms underlying the emergence of tissue level arrhythmias from cellular level EADs is not fully understood. Another known arrhythmogenic condition is fibrosis of cardiac tissue that occurs both due to aging and in many types of heart diseases. In this paper we describe the results of a systematic insilico study, using the TNNP model of human cardiac cells and MacCannell model for (myo) fibroblasts, on the possible effects of diffuse fibrosis on arrhythmias...
AbstractReduced conduction velocity (CV) in the myocardium is well known to increase the probability...
Currently, treatment of arrhythmias is largely symptomatic and pro-arrhythmic mechanisms are incompl...
Atrial fibrillation (AF) associated with fibrosis is characterized by the appearance of interstitial...
Managing lethal cardiac arrhythmias is one of the biggest challenges in modern cardiology, and hence...
Myocardial injury, mechanical stress, neurohormonal activation, inflammation, and/or aging all lead ...
AbstractAtrial fibrosis has been implicated in the development and maintenance of atrial arrhythmias...
In the healthy heart, cardiac myocytes form an electrical syncytium embedded in a supportive fibrobl...
Myocardial fibrosis is an important risk factor for cardiac arrhythmias. Previous experimental and n...
AbstractFibroblasts are electrophysiologically quiescent in the healthy heart. Evidence suggests tha...
Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in ...
Roughly 75% of normal myocardial tissue volume is comprised of myocytes, however, fibroblasts by num...
Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in ...
Myocardial fibrosis is an important risk factor for cardiac arrhythmias. Previous experimental and n...
The adult heart is composed of a dense network of cardiomyocytes surrounded by nonmyocytes, the most...
Fibrosis has been mechanistically linked to arrhythmogenesis in multiple cardiovascular conditions, ...
AbstractReduced conduction velocity (CV) in the myocardium is well known to increase the probability...
Currently, treatment of arrhythmias is largely symptomatic and pro-arrhythmic mechanisms are incompl...
Atrial fibrillation (AF) associated with fibrosis is characterized by the appearance of interstitial...
Managing lethal cardiac arrhythmias is one of the biggest challenges in modern cardiology, and hence...
Myocardial injury, mechanical stress, neurohormonal activation, inflammation, and/or aging all lead ...
AbstractAtrial fibrosis has been implicated in the development and maintenance of atrial arrhythmias...
In the healthy heart, cardiac myocytes form an electrical syncytium embedded in a supportive fibrobl...
Myocardial fibrosis is an important risk factor for cardiac arrhythmias. Previous experimental and n...
AbstractFibroblasts are electrophysiologically quiescent in the healthy heart. Evidence suggests tha...
Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in ...
Roughly 75% of normal myocardial tissue volume is comprised of myocytes, however, fibroblasts by num...
Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in ...
Myocardial fibrosis is an important risk factor for cardiac arrhythmias. Previous experimental and n...
The adult heart is composed of a dense network of cardiomyocytes surrounded by nonmyocytes, the most...
Fibrosis has been mechanistically linked to arrhythmogenesis in multiple cardiovascular conditions, ...
AbstractReduced conduction velocity (CV) in the myocardium is well known to increase the probability...
Currently, treatment of arrhythmias is largely symptomatic and pro-arrhythmic mechanisms are incompl...
Atrial fibrillation (AF) associated with fibrosis is characterized by the appearance of interstitial...