BACKGROUND: Myosin Va is a motor protein involved in vesicular transport and its absence leads to movement disorders in humans (Griscelli and Elejalde syndromes) and rodents (e.g. dilute lethal phenotype in mice). We examined the role of myosin Va in the postsynaptic plasticity of the vertebrate neuromuscular junction (NMJ). METHODOLOGY/PRINCIPAL FINDINGS: Dilute lethal mice showed a good correlation between the propensity for seizures, and fragmentation and size reduction of NMJs. In an aneural C2C12 myoblast cell culture, expression of a dominant-negative fragment of myosin Va led to the accumulation of punctate structures containing the NMJ marker protein, rapsyn-GFP, in perinuclear clusters. In mouse hindlimb muscle, endogenous myosin V...
Canonical Wnt signaling is involved in skeletal muscle cell biology. The exact way in which this pat...
The motor neuron disease spinal muscular atrophy (SMA) causes profound muscle weakness that most oft...
Impulse transmission from the axons of motor neurons to the myofibers of our muscles is essential fo...
BACKGROUND: Myosin Va is a motor protein involved in vesicular transport and its absence leads to mo...
BACKGROUND: Myosin Va is a motor protein involved in vesicular transport and its absence leads to mo...
Background: Myosin Va is a motor protein involved in vesicular transport and its absence leads to mo...
BACKGROUND: The unconventional motor protein, myosin Va, is crucial for the development of the mouse...
Background: The unconventional motor protein, myosin Va, is crucial for the development of the mouse...
BACKGROUND: The unconventional motor protein, myosin Va, is crucial for the development of the mouse...
Myosin V motor proteins facilitate recycling of synaptic receptors, including AMPA and acetylcholine...
UnrestrictedThe synapse is the fundamental building block of the brain circuitry responsible for the...
Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease in which weakness, increase...
Proper neuronal development and function requires precise sorting and delivery of various elements f...
We investigated the axonal transport of neurofilaments in cultured neurons from two different strain...
The vertebrate neuromuscular junction (NMJ), a peripheral synapse formed between motoneuron and skel...
Canonical Wnt signaling is involved in skeletal muscle cell biology. The exact way in which this pat...
The motor neuron disease spinal muscular atrophy (SMA) causes profound muscle weakness that most oft...
Impulse transmission from the axons of motor neurons to the myofibers of our muscles is essential fo...
BACKGROUND: Myosin Va is a motor protein involved in vesicular transport and its absence leads to mo...
BACKGROUND: Myosin Va is a motor protein involved in vesicular transport and its absence leads to mo...
Background: Myosin Va is a motor protein involved in vesicular transport and its absence leads to mo...
BACKGROUND: The unconventional motor protein, myosin Va, is crucial for the development of the mouse...
Background: The unconventional motor protein, myosin Va, is crucial for the development of the mouse...
BACKGROUND: The unconventional motor protein, myosin Va, is crucial for the development of the mouse...
Myosin V motor proteins facilitate recycling of synaptic receptors, including AMPA and acetylcholine...
UnrestrictedThe synapse is the fundamental building block of the brain circuitry responsible for the...
Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease in which weakness, increase...
Proper neuronal development and function requires precise sorting and delivery of various elements f...
We investigated the axonal transport of neurofilaments in cultured neurons from two different strain...
The vertebrate neuromuscular junction (NMJ), a peripheral synapse formed between motoneuron and skel...
Canonical Wnt signaling is involved in skeletal muscle cell biology. The exact way in which this pat...
The motor neuron disease spinal muscular atrophy (SMA) causes profound muscle weakness that most oft...
Impulse transmission from the axons of motor neurons to the myofibers of our muscles is essential fo...