In vivo activity of next generation synthetic ozonides against Schistosoma species

We evaluated the in vivo antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult Schistosoma mansoni with total and female worm burden reductions of 80 and 90% (p < 0.05). Furthermore, treatment of S. haematobium infected mice with OZ418 reduced total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compoun