Transcriptional and translational regulation of glutamate receptor expression determines one of the key phenotypic features of neurons in the brain-the properties of their excitatory synaptic receptors. Up- and down-regulation of various glutamate receptor subunits occur throughout development, following ischemia, seizures, repetitive activation of afferents, or chronic administration of a variety of drugs. The promoters of the genes that encode the NR1, NR2B, NR2C, GluR1, GluR2, and KA2 subunits share several characteristics that include multiple transcriptional start sites within a CpG island, lack of TATA and CAAT boxes, and neuronal-selective expression. In most cases, the promoter regions include overlapping Sp1 and GSG motifs near the...
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian cent...
Glutamate is the principal excitatory neurotransmitter in the brain. Glutamate activates cation-sele...
Stimulation of group I metabotropic glutamate receptors (mGluRs) initiates a wide variety of signali...
The GluR1 glutamate receptor subunit is expressed in most brain areas and plays a major role in exci...
Objectives: The regulation of genes involved in glutamatergic function is thought to be a critical f...
The ligand-gated receptors for L-glutamate play a central role in acute neuronal degeneration. Recen...
The NMDA receptor channel plays a key role in activity-dependent synaptic plasticity such as long-te...
Glutamate receptor channels are built around an ancient pore loop structure which defines the inner ...
Abstract Glutamate and its receptors are expressed very early during development and may play import...
GABA type-A receptors are essential for fast inhibitory neurotransmission and are critical in brain ...
The NMDA type of glutamate receptors plays a crucial role in the induction of long term synaptic pot...
Rapid excitatory neurotransmission in the central nervous system (CNS) is mediated predominantly by ...
The glutamate receptor channel plays a key role in brain function. Most of the fast excitatory synap...
To understand how neurons control the expression of the AMPA receptor subunit GluR2, we cloned the 5...
Ionotropic ligand-gated channels constitute a messenger RNA (alternative splicing, editing) and subl...
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian cent...
Glutamate is the principal excitatory neurotransmitter in the brain. Glutamate activates cation-sele...
Stimulation of group I metabotropic glutamate receptors (mGluRs) initiates a wide variety of signali...
The GluR1 glutamate receptor subunit is expressed in most brain areas and plays a major role in exci...
Objectives: The regulation of genes involved in glutamatergic function is thought to be a critical f...
The ligand-gated receptors for L-glutamate play a central role in acute neuronal degeneration. Recen...
The NMDA receptor channel plays a key role in activity-dependent synaptic plasticity such as long-te...
Glutamate receptor channels are built around an ancient pore loop structure which defines the inner ...
Abstract Glutamate and its receptors are expressed very early during development and may play import...
GABA type-A receptors are essential for fast inhibitory neurotransmission and are critical in brain ...
The NMDA type of glutamate receptors plays a crucial role in the induction of long term synaptic pot...
Rapid excitatory neurotransmission in the central nervous system (CNS) is mediated predominantly by ...
The glutamate receptor channel plays a key role in brain function. Most of the fast excitatory synap...
To understand how neurons control the expression of the AMPA receptor subunit GluR2, we cloned the 5...
Ionotropic ligand-gated channels constitute a messenger RNA (alternative splicing, editing) and subl...
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian cent...
Glutamate is the principal excitatory neurotransmitter in the brain. Glutamate activates cation-sele...
Stimulation of group I metabotropic glutamate receptors (mGluRs) initiates a wide variety of signali...