Genetic variation in the SLC8A1 calcium signaling pathway is associated with susceptibility to Kawasaki disease and coronary artery abnormalities
- Shimizu, Chisato
- Eleftherohorinou, Hariklia
- Wright, Victoria J.
- Kim, Jihoon
- Alphonse, Martin P.
- Perry, James C.
- Cimaz, Rolando
- Burgner, David
- Dahdah, Nagib
- Hoang, Long T.
- Khor, Chiea Chuen
- Salgado, Andrea
- Tremoulet, Adriana H.
- Davila, Sonia
- Kuijpers, Taco W.
- Hibberd, Martin L.
- Johnson, Todd A.
- Takahashi, Atsushi
- Tsunoda, Tatsuhiko
- Kubo, Michiaki
- Tanaka, Toshihiro
- Onouchi, Yoshihiro
- Yeung, Rae S. M.
- Coin, Lachlan J. M.
- Levin, Michael
- Burns, Jane C.
Publication date
December 2016
DOI Publisher
Ovid Technologies (Wolters Kluwer Health)Abstract
Background-Kawasaki disease (KD) is an acute pediatric vasculitis in which host genetics influence both susceptibility to KD and the formation of coronary artery aneurysms. Variants discovered by genome-wide association studies and linkage studies only partially explain the influence of genetics on KD susceptibility. Methods and Results-To search for additional functional genetic variation, we performed pathway and gene stability analysis on a genome-wide association study data set. Pathway analysis using European genome-wide association study data identified 100 significantly associated pathways (
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