Genome-wide association for major depression through age at onset stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
- Power, Robert A.
- Tansey, Katherine E.
- Buttenschøn, Henriette Nørmølle
- Cohen-Woods, Sarah
- Bigdeli, Tim
- Hall, Lynsey S.
- Kutalik, Zoltán
- Lee, S. Hong
- Ripke, Stephan
- Steinberg, Stacy
- Teumer, Alexander
- Viktorin, Alexander
- Wray, Naomi R.
- Arolt, Volker
- Baune, Bernard T.
- Boomsma, Dorret I.
- Børglum, Anders D.
- Byrne, Enda M.
- Castelao, Enrique
- Craddock, Nick
- Craig, Ian
- Dannlowski, Udo
- Deary, Ian J.
- Degenhardt, Franziska
- Forstner, Andreas J.
- Gordon, Scott D.
- Grabe, Hans J.
- Grove, Jakob
- Hamilton, Steven P.
- Hayward, Caroline
- Heath, Andrew C.
DOIAbstract
Major depressive disorder (MDD) is a disabling mood disorder, and despite a known heritable component, a large meta-analysis of genome-wide association studies revealed no replicable genetic risk variants. Given prior evidence of heterogeneity by age at onset in MDD, we tested whether genome-wide significant risk variants for MDD could be identified in cases subdivided by age at onset
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