A DNA methylation biomarker of alcohol consumption.
- Liu, C
- Marioni, RE
- Hedman, ÅK
- Pfeiffer, L
- Tsai, P-C
- Reynolds, LM
- Just, AC
- Duan, Q
- Boer, CG
- Tanaka, T
- Elks, Cathy
- Aslibekyan, S
- Brody, JA
- Kühnel, B
- Herder, C
- Almli, LM
- Zhi, D
- Wang, Y
- Huan, T
- Yao, C
- Mendelson, MM
- Joehanes, R
- Liang, L
- Love, S-A
- Guan, W
- Shah, S
- McRae, AF
- Kretschmer, A
- Prokisch, H
- Strauch, K
- Peters, A
- Visscher, PM
- Wray, NR
- Guo, X
- Wiggins, KL
- Smith, AK
- Binder, EB
- Ressler, KJ
- Irvin, MR
- Absher, DM
- Hernandez, D
- Ferrucci, L
- Bandinelli, S
- Lohman, K
- Ding, J
- Trevisi, L
- Gustafsson, S
- Sandling, JH
- Stolk, L
- Uitterlinden, AG
- Yet, I
- Castillo-Fernandez, JE
- Spector, TD
- Schwartz, JD
- Vokonas, P
- Lind, L
- Li, Y
- Fornage, M
- Arnett, DK
- Wareham, Nicholas
- Sotoodehnia, N
- Ong, Kenneth
- van Meurs, JBJ
- Conneely, KN
- Baccarelli, AA
- Deary, IJ
- Bell, JT
- North, KE
- Liu, Y
- Waldenberger, M
- London, SJ
- Ingelsson, E
- Levy, D
DOIAbstract
The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation may provide novel biomarkers of alcohol use. To examine this possibility, we performed an epigenome-wide association study of methylation of cytosine-phosphate-guanine dinucleotide (CpG) sites in relation to alcohol intake in 13 population-based cohorts (ntotal=13 317; 54% women; mean age across cohorts 42-76 years) using whole blood (9643 European and 2423 African ancestries) or monocyte-derived DNA (588 European, 263 African and 400 Hispanic ancestry) samples. We performed meta-analysis and variable selection in whole-blood samples of people of European ancestry (n...
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