Morphogenesis of post-stenotic aortic dilatation: Expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in aortic media.

Aim: To evaluate the impact of the enzyme extracellular matrix metalloproteinases inducer (EMMRPIN) in morphogenesis of aortic dilatation due do aortic valve stenosis. Objectives: To evaluate the impact and compare the expression of EMMPRIN in aortic samples in patients with and without aortic valve stenosis and dilatative pathology. Results: The expression of EMMPRIN was present and significantly higher in the SMC of aortic walls taken from patients with DPATA when compared with control specimens. The median score of expression of EMMPRIN in the study group with dilatative pathology due to post-stenotic dilatation was 3 (range 0-6), while the median score of expression of EMMPRIN in the reference group without dilatative pathology was 1 (range 0-4). There was a significant higher expression of EMMPRIN in the DPAA study group compared to the reference group (p=0.0079). Conclusion: We found that there is a higher expression of EMMPRIN in DPAA; this might affect the expression MMPs, the organization of collagen fibrils and the organization of elastic fibrils, and thereby the pathogenesis of aortic aneurysmal diseases