Kepenų fibroze ir ciroze sergančių ligonių genetinės ypatybės

[...]. The aim of the study. To investigate a role of mutations in HFE gene and genetic variants in PNPLA3, PNF7, MERTK, PCSK7 genes in patients with liver fibrosis and liver cirrhosis. The objectives of the study. 1. To determine the association between HFE gene C282Y and H63D mutations and liver cirrhosis. 2. To determine association between gender and HFE gene C282Y and H63D mutations in liver cirrhosis patients. 3. To investigate associations between key PNPLA3,, RNF7, MERTK and PCSK7 gene polymorphisms and liver fibrosis. 4. To investigate associations between key PNPLA3, RNF7, MERTJ and PCSK7 gene polymorphisms and liver cirrhosis. 5. To determine association of PNPLA3, RNF7, MERTK and PCSK7 gene polymorphisms with hepatitis C virus - induced and non-hepatitic C virus - induced liver cirrhosis and fibrosis. Novelty of the study. In the past two decades, our knowldge about the genetic deternminants of liver diseases has expanded rapidly. [...]