PALIASA LEAF (KLEINHOVIA HOSPITA LINN.) EXTRACT CAN PREVENT HEPATOTOXICITY INDUCED BY CHRONIC USE OF HIGH DOSE PARACETAMOL

Paracetamol is a common treatment for fever, however, it may induce hepatotoxicity, especially with chronic use in high dose. Paliasa leaves (Kleinhovia hospita Linn) have been traditionally used to treat chronic hepatitis in South Sulawesi. This study aimed to investigate hepatoprotective effect of Paliasa leaf extract against chronic use of high dose paracetamol through histopathology examination. Paliasa leaves were exracted with etanol 70% by maseration and made into 5%, 10% and 15% b/v concentration. Mice (n=25) divided into 5 treatment groups: I (controls); II administration of paracetamol 200 mg/kg/day for 7 days; III, IV and V treatment with Paliasa extract 5%, 10% and 15 %b/v, respectively, 30 minutes after paracetamol (200 mg/kg) administration for 7 days. Liver histopathology examination was conducted 24 hour from the treatment period. The result shows that multiple dose of paracetamol (200 mg/kg) caused intensive haemorrhage and congestion, fatty degeneration, centrolobular necrosis and profound megalocytosis. Paliasa extract treatment significantly reduced the presence of haemorrhage, megalocytosis and hepatocyte degeneration, especially with 15%b/v concentration (p