The incidence of invasive Haemophilus influenzae type b (Hib) disease has significantly decreased since the introduction of an efficient vaccine against Hib. However, in contrast to Hib, infections caused by H. influenzae serotype f (Hif) are emerging. We recently did a whole genome sequencing of an invasive Hif isolate, and reported that Hif interacts with factor H by expressing protein H (PH). In this study, upon screening with various human complement regulators, we revealed that PH is also a receptor for vitronectin (Vn), an abundant plasma protein that regulates the terminal pathway of the human complement system in addition to being a component of the extracellular matrix. Bacterial Vn binding was significantly reduced when the lph ge...
Many pathogens express a surface protein that binds the human complement regulator factor H (FH), as...
The human pathogen Haemophilus influenzae causes mainly respiratory tract infections such as acute o...
<div><p>Many pathogens express a surface protein that binds the human complement regulator factor H ...
Acquisition of the complement inhibitor vitronectin (Vn) is important for the respiratory tract path...
Haemophilus influenzae is a Gram-negative human pathogen that resides in the upper respiratory tract...
Haemophilus influenzae is an important respiratory tract pathogen responsible for a variety of infec...
Pathogenic microbes acquire human complement inhibitors to circumvent the innate immune system. In t...
Nontypeable Haemophilus influenzae (NTHi) commonly causes local disease in the upper and lower respi...
Haemophilus influenzae is a human specific Gram-negative respiratory tract pathogen. Encapsulated H....
Haemophilus influenzae protein E (PE) is a 16 kDa adhesin that induces a pro-inflammatory immune res...
Bacteria utilize complement regulators as a means of evading the host immune response. Here, we desc...
Haemophilus influenzae colonizes the human respiratory tract, and is a major source of disease. Anti...
Streptococcus pneumoniae serotype 3 strains are highly resistant to opsonophagocytosis due to recrui...
Many pathogens express a surface protein that binds the human complement regulator factor H (FH), as...
Many pathogens express a surface protein that binds the human complement regulator factor H (FH), as...
Many pathogens express a surface protein that binds the human complement regulator factor H (FH), as...
The human pathogen Haemophilus influenzae causes mainly respiratory tract infections such as acute o...
<div><p>Many pathogens express a surface protein that binds the human complement regulator factor H ...
Acquisition of the complement inhibitor vitronectin (Vn) is important for the respiratory tract path...
Haemophilus influenzae is a Gram-negative human pathogen that resides in the upper respiratory tract...
Haemophilus influenzae is an important respiratory tract pathogen responsible for a variety of infec...
Pathogenic microbes acquire human complement inhibitors to circumvent the innate immune system. In t...
Nontypeable Haemophilus influenzae (NTHi) commonly causes local disease in the upper and lower respi...
Haemophilus influenzae is a human specific Gram-negative respiratory tract pathogen. Encapsulated H....
Haemophilus influenzae protein E (PE) is a 16 kDa adhesin that induces a pro-inflammatory immune res...
Bacteria utilize complement regulators as a means of evading the host immune response. Here, we desc...
Haemophilus influenzae colonizes the human respiratory tract, and is a major source of disease. Anti...
Streptococcus pneumoniae serotype 3 strains are highly resistant to opsonophagocytosis due to recrui...
Many pathogens express a surface protein that binds the human complement regulator factor H (FH), as...
Many pathogens express a surface protein that binds the human complement regulator factor H (FH), as...
Many pathogens express a surface protein that binds the human complement regulator factor H (FH), as...
The human pathogen Haemophilus influenzae causes mainly respiratory tract infections such as acute o...
<div><p>Many pathogens express a surface protein that binds the human complement regulator factor H ...