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Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population

  • Tai, E. Shyong
  • Sim, Xue Ling
  • Ong, Twee Hee
  • Wong, Tien Yin
  • Saw, Seang Mei
  • Aung, Tin
  • Kathiresan, Sekar
  • Orho-Melander, Marju
  • Ordovas, Jose M.
  • Tan, Jonathan T.
  • Seielstad, Mark
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Publication date
January 2009
Icon DOI
10.1194/jlr.M800456-JLR200
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)

Abstract

We conducted a cross-sectional study of Malay articipants aged 40-80 years (n = 2,932) to examine the associations between polymorphisms at newly identified, lipid-associated loci with blood lipid levels and prevalent cardiovascular disease (CVD) in a Malay population in Asia. A polymorphism adjacent to the TRIB1 locus (rs17321515) was associated with elevated total cholesterol and LDL-cholesterol (LDL-C) after adjustment for age and sex (both P values <0.007) and with increased risk of coronary heart disease and CVD [odds ratio (OR) 1.23, 95% confidence interval (95% CI) 1.03-1.46; and OR 1.2, 95% CI 1.02-1.42, respectively] under an additive model of inheritance. In addition, using recessive models of inheritance, polymorphisms on chromos...

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