Mutations in the hepatocyte nuclear factor 1-alpha gene (HNF-1 alpha, now known as the transcription factor 1 gene [TCF1]) cause the most common monogenic form of diabetes, MODY3, but it is not known if common variants in HNF-1a are associated with decreased transcriptional activity or phenotypes related to type 2 diabetes, or whether they predict future type 2 diabetes. We studied the effect of four common polymorphisms (rs1920792, I27L, A98V and S487N) in and upstream of the HNF-1 alpha gene on transcriptional activity in vitro, and their possible association with type 2 diabetes and insulin secretion in vivo. Certain combinations of the I27L and A98V polymorphisms in the HNF-1 alpha gene showed decreased transcriptional activity on the t...
There is wide variation in the age at diagnosis of diabetes in individuals with Maturity-Onset Diabe...
AIMS/HYPOTHESIS: The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator...
Two recent publications reported association of common polymorphisms in the P2 promoter of hepatocyt...
Mutations in the hepatocyte nuclear factor 1-alpha gene (HNF-1 alpha, now known as the transcription...
Aims/hypothesis: Mutations in the hepatocyte nuclear factor 1-α gene (HNF-1α, now known as the trans...
It is currently unclear how often genes that are mutated to cause rare, early-onset monogenic forms ...
Variants in HNF1A encoding hepatocyte nuclear factor 1α (HNF-1A) are associated with maturity-onset ...
Variants in HNF1A encoding hepatocyte nuclear factor 1a (HNF-1A) are associated with maturity-onset ...
OBJECTIVE-Mutations in the hepatocyte nuclear factor (HNF)-1 alpha, HNF-4 alpha, glucokinase (GCK), ...
Variants in the transcription factor gene HNF1A have been identified in subjects with maturity-onset...
Rare mutations in the gene HNF4A, encoding the transcription factor hepatocyte nuclear factor 4&alph...
THE disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by abnormally ...
Aims/hypothesis Rare mutations in the gene HNF4A, encoding the transcription factor hepatocyte nucle...
HNF1alpha (TCF1) is a key transcription factor that is essential for pancreatic beta-cell developmen...
β-Cell transcription factor genes are important in the pathophysiology of the β-cell, with mutations...
There is wide variation in the age at diagnosis of diabetes in individuals with Maturity-Onset Diabe...
AIMS/HYPOTHESIS: The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator...
Two recent publications reported association of common polymorphisms in the P2 promoter of hepatocyt...
Mutations in the hepatocyte nuclear factor 1-alpha gene (HNF-1 alpha, now known as the transcription...
Aims/hypothesis: Mutations in the hepatocyte nuclear factor 1-α gene (HNF-1α, now known as the trans...
It is currently unclear how often genes that are mutated to cause rare, early-onset monogenic forms ...
Variants in HNF1A encoding hepatocyte nuclear factor 1α (HNF-1A) are associated with maturity-onset ...
Variants in HNF1A encoding hepatocyte nuclear factor 1a (HNF-1A) are associated with maturity-onset ...
OBJECTIVE-Mutations in the hepatocyte nuclear factor (HNF)-1 alpha, HNF-4 alpha, glucokinase (GCK), ...
Variants in the transcription factor gene HNF1A have been identified in subjects with maturity-onset...
Rare mutations in the gene HNF4A, encoding the transcription factor hepatocyte nuclear factor 4&alph...
THE disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by abnormally ...
Aims/hypothesis Rare mutations in the gene HNF4A, encoding the transcription factor hepatocyte nucle...
HNF1alpha (TCF1) is a key transcription factor that is essential for pancreatic beta-cell developmen...
β-Cell transcription factor genes are important in the pathophysiology of the β-cell, with mutations...
There is wide variation in the age at diagnosis of diabetes in individuals with Maturity-Onset Diabe...
AIMS/HYPOTHESIS: The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator...
Two recent publications reported association of common polymorphisms in the P2 promoter of hepatocyt...