Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort
- Duell, Eric J.
- Travier, Noemie
- Lujan-Barroso, Leila
- Dossus, Laure
- Boutron-Ruault, Marie-Christine
- Clavel-Chapelon, Francoise
- Tumino, Rosario
- Masala, Giovanna
- Krogh, Vittorio
- Panico, Salvatore
- Ricceri, Fulvio
- Luisa Redondo, Maria
- Dorronsoro, Miren
- Molina-Montes, Esther
- Huerta, Jose M.
- Barricarte, Aurelio
- Khaw, Kay-Tee
- Wareham, Nick J.
- Allen, Naomi E.
- Travis, Ruth
- Siersema, Peter D.
- Peeters, Petra H. M.
- Trichopoulou, Antonia
- Fragogeorgi, Eirini
- Oikonomou, Eleni
- Boeing, Heiner
- Schuetze, Madlen
- Canzian, Federico
- Lukanova, Annekatrin
- Tjonneland, Anne
- Roswall, Nina
- Overvad, Kim
- Weiderpass, Elisabete
- Gram, Inger Torhild
- Lund, Eiliv
- Lindkvist, Bjorn
- Johansen, Dorthe
- Ye, Weimin
- Sund, Malin
- Fedirko, Veronika
- Jenab, Mazda
- Michaud, Dominique S.
- Riboli, Elio
- Bueno-de-Mesquita, H. Bas
DOIAbstract
Menstrual and reproductive factors and exogenous hormone use have been investigated as pancreatic cancer risk factors in case-control and cohort studies, but results have been inconsistent. We conducted a prospective examination of menstrual and reproductive factors, exogenous hormone use and pancreatic cancer risk (based on 304 cases) in 328,610 women from the EPIC cohort. Then, in a case-control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). Of all factors analyzed, only younger age at menarche (<12 vs. 13 years) was moderately associated with an increase...
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