Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study.
- Langenberg, Claudia
- Sharp, Stephen J
- Franks, Paul
- Scott, Robert A
- Deloukas, Panos
- Forouhi, Nita G
- Froguel, Philippe
- Groop, Leif
- Hansen, Torben
- Palla, Luigi
- Pedersen, Oluf
- Schulze, Matthias B
- Tormo, Maria-Jose
- Wheeler, Eleanor
- Agnoli, Claudia
- Arriola, Larraitz
- Barricarte, Aurelio
- Boeing, Heiner
- Clarke, Geraldine M
- Clavel-Chapelon, Françoise
- Duell, Eric J
- Fagherazzi, Guy
- Kaaks, Rudolf
- Kerrison, Nicola D
- Key, Timothy J
- Khaw, Kay Tee
- Kröger, Janine
- Lajous, Martin
- Morris, Andrew P
- Navarro, Carmen
- Nilsson, Peter
- Overvad, Kim
- Palli, Domenico
- Panico, Salvatore
- Quirós, J Ramón
- Rolandsson, Olov
- Sacerdote, Carlotta
- Sánchez, María-José
- Slimani, Nadia
- Spijkerman, Annemieke M W
- Tumino, Rosario
- van der A, Daphne L
- van der Schouw, Yvonne T
- Barroso, Inês
- McCarthy, Mark I
- Riboli, Elio
- Wareham, Nicholas J
Publication date
January 2014
DOI Publisher
Public Library of Science (PLoS)Abstract
Understanding of the genetic basis of type 2 diabetes (T2D) has progressed rapidly, but the interactions between common genetic variants and lifestyle risk factors have not been systematically investigated in studies with adequate statistical power. Therefore, we aimed to quantify the combined effects of genetic and lifestyle factors on risk of T2D in order to inform strategies for prevention