Quinoline-3-carboxamides (Q-compounds) are currently in clinical development for both autoimmune disease and cancer. We have previously shown that the Q-compound paquinimod (ABR-215757) significantly ameliorates disease symptoms in several mouse models of human inflammatory disease. Considering that recruitment of inflammatory cells into tissue is a common denominator of these models, we have in this report investigated whether paquinimod would interfere with cell accumulation during sterile peritoneal inflammation. To mimic the cell recruitment elicited by tissue injury, we used necrotic cells to induce the acute inflammatory response. We show that per oral treatment with paquinimod significantly reduced the accumulation of Ly6C(hi) inflam...
Introduction: Quinoline-3-carboximide compounds, such as paquinimod, which targets the protein S100A...
The quinoline-3-carboxamide ABR-215757 (5757) is in clinical development for the treatment of human ...
BACKGROUND: We have recently released the structure of a class of quinolin-2-(1H)-on-3-carboxamide d...
The quinoline-3-carboxamides (Q compounds) are a family of small molecules that ameliorate various t...
Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properti...
Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properti...
ABR-215757 (5757) is a quinoline-3-carboxamide (Q-compound) currently in clinical development for sy...
Quinoline-3-carboxamides are currently in clinical development for treatment of both autoimmune dise...
<div><p>Quinoline-3-carboxamides (Q compounds) are immunomodulatory compounds that have shown effica...
Background. Quinoline-3-carboxamides have been used to treat autoimmune/inflammatory diseases in hum...
The effect of a quinoline-3-carboxamide on the T-cell-dependent B-cell response was investigated in ...
Laquinimod is a novel oral drug that is currently being evaluated for the treatment of relapsing-rem...
Background: Systemic Sclerosis (SSc) is an autoimmune disease characterized by vascular and immune d...
AbstractBackgroundSystemic Sclerosis (SSc) is an autoimmune disease characterized by vascular and im...
AbstractIntroductionQuinoline-3-carboximide compounds, such as paquinimod, which targets the protein...
Introduction: Quinoline-3-carboximide compounds, such as paquinimod, which targets the protein S100A...
The quinoline-3-carboxamide ABR-215757 (5757) is in clinical development for the treatment of human ...
BACKGROUND: We have recently released the structure of a class of quinolin-2-(1H)-on-3-carboxamide d...
The quinoline-3-carboxamides (Q compounds) are a family of small molecules that ameliorate various t...
Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properti...
Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properti...
ABR-215757 (5757) is a quinoline-3-carboxamide (Q-compound) currently in clinical development for sy...
Quinoline-3-carboxamides are currently in clinical development for treatment of both autoimmune dise...
<div><p>Quinoline-3-carboxamides (Q compounds) are immunomodulatory compounds that have shown effica...
Background. Quinoline-3-carboxamides have been used to treat autoimmune/inflammatory diseases in hum...
The effect of a quinoline-3-carboxamide on the T-cell-dependent B-cell response was investigated in ...
Laquinimod is a novel oral drug that is currently being evaluated for the treatment of relapsing-rem...
Background: Systemic Sclerosis (SSc) is an autoimmune disease characterized by vascular and immune d...
AbstractBackgroundSystemic Sclerosis (SSc) is an autoimmune disease characterized by vascular and im...
AbstractIntroductionQuinoline-3-carboximide compounds, such as paquinimod, which targets the protein...
Introduction: Quinoline-3-carboximide compounds, such as paquinimod, which targets the protein S100A...
The quinoline-3-carboxamide ABR-215757 (5757) is in clinical development for the treatment of human ...
BACKGROUND: We have recently released the structure of a class of quinolin-2-(1H)-on-3-carboxamide d...