BACKGROUND: The breaking strength of colonic anastomoses declines after operation to a minimum at days 3-4, with a subsequent risk of anastomotic dehiscence. The mechanism is thought to be collagen degradation by matrix metalloproteinases (MMPs). This study examined the pathogenic role of MMPs on the mechanical strength of colonic anastomoses by giving the synthetic broad-spectrum MMP inhibitor BB-1101 systemically. METHODS: Forty-eight male Sprague-Dawley rats were treated daily for 7 days with BB-1101 30 mg/kg or vehicle alone (control) starting 2 days before operation. The breaking strength of standardized left-sided colonic anastomoses was measured on postoperative days 1, 3 and 7. RESULTS: Serum BB-1101 levels were increased at 100 nmo...
Purpose: Anastomotic leakage (AL) is the most severe complication following colorectal resection and...
Item does not contain fulltextPURPOSE: Early postoperative strength in intestinal anastomoses is red...
Background. Rectal cancer is one of the malignant diseases with high morbidity and mortality in the ...
PURPOSE: Submucosal collagen is paramount for colonic anastomotic integrity. Matrix metalloproteinas...
Item does not contain fulltextBACKGROUND AND AIMS: The strength of intestinal anastomoses is relativ...
Background. Dehiscence of colon anastomosis is a common, serious and potentially life-threatening co...
PURPOSE: Emergency resections for colonic obstruction are accompanied with increased risk of anastom...
Indirect evidence has suggested that collagenase, an enzyme that specifically degrades collagen is r...
Colorectal cancer is one of the most common malignant diseases world-wide. Most patients can be diag...
Item does not contain fulltextBACKGROUND: Clinical studies report conflicting results on the safety ...
Emergency operations performed on an obstructed colon are accompanied by an increased risk of anasto...
Background and aims: After resection and repair of the intestines, tissue degradation leads to weake...
Item does not contain fulltextBACKGROUND: The strength of intestinal anastomoses is relatively low i...
Anastomotic dehiscence is the most severe complication of colorectal surgery. Metalloproteinases (MM...
PURPOSE: The strength of the uninjured and anastomosed intestinal wall is determined by its submucos...
Purpose: Anastomotic leakage (AL) is the most severe complication following colorectal resection and...
Item does not contain fulltextPURPOSE: Early postoperative strength in intestinal anastomoses is red...
Background. Rectal cancer is one of the malignant diseases with high morbidity and mortality in the ...
PURPOSE: Submucosal collagen is paramount for colonic anastomotic integrity. Matrix metalloproteinas...
Item does not contain fulltextBACKGROUND AND AIMS: The strength of intestinal anastomoses is relativ...
Background. Dehiscence of colon anastomosis is a common, serious and potentially life-threatening co...
PURPOSE: Emergency resections for colonic obstruction are accompanied with increased risk of anastom...
Indirect evidence has suggested that collagenase, an enzyme that specifically degrades collagen is r...
Colorectal cancer is one of the most common malignant diseases world-wide. Most patients can be diag...
Item does not contain fulltextBACKGROUND: Clinical studies report conflicting results on the safety ...
Emergency operations performed on an obstructed colon are accompanied by an increased risk of anasto...
Background and aims: After resection and repair of the intestines, tissue degradation leads to weake...
Item does not contain fulltextBACKGROUND: The strength of intestinal anastomoses is relatively low i...
Anastomotic dehiscence is the most severe complication of colorectal surgery. Metalloproteinases (MM...
PURPOSE: The strength of the uninjured and anastomosed intestinal wall is determined by its submucos...
Purpose: Anastomotic leakage (AL) is the most severe complication following colorectal resection and...
Item does not contain fulltextPURPOSE: Early postoperative strength in intestinal anastomoses is red...
Background. Rectal cancer is one of the malignant diseases with high morbidity and mortality in the ...