Guanylate cyclase activating protein 1 (GCAP1) is a neuronal Ca2+ sensor (NCS) that regulates the activation of rod outer segment guanylate cyclases (ROS-GCs) in photoreceptors. In this study, we investigated the Ca2+-induced effects on the conformation and the thermal stability of four GCAP1 variants associated with hereditary human cone dystrophies. Ca2+ binding stabilized the conformation of all the GCAP1 variants independent of myristoylation. The myristoylated wild-type GCAP1 was found to have the highest Ca2+ affinity and thermal stability, whereas all the mutants showed decreased Ca2+ affinity and significantly lower thermal stability in both apo and Ca2+-loaded forms. No apparent cooperativity of Ca2+ binding was detected for any va...
Rod outer segment membrane guanylate cyclase1 (ROS-GC1) is the original member of the membrane guany...
Two recently identified missense mutations (p. L84F and p. I107T) in GUCA1A, the gene coding for gua...
Guanylate cyclase activating protein-1 (GCAP1) is required for activation of retinal guanylate cycla...
Guanylate cyclase activating protein 1 (GCAP1) is a neuronal Ca 2+ sensor (NCS) that regulates the a...
Progressive visual impairment leading to blindness is often associated with inherited retinal dystro...
Guanylate cyclase-activating protein 1 (GCAP1), encoded by the GUCA1A gene, is a neuronal calcium se...
Purpose Photoreceptor cells efficiently respond to changing light conditions on a millisecond times...
Guanylate Cyclase Activating Protein 1 (GCAP1) regulates the enzymatic activity of the photoreceptor...
The GUCA1A gene encodes the guanylate cyclase activating protein 1 (GCAP1) of mammalian rod and co...
Purpose Cone dystrophies are often associated with altered levels of calcium (Ca2+) and cyclic GMP ...
Cone dystrophy-related mutations in guanylate cyclase-activating protein 1 (GCAP1) are known to caus...
Mutations in the gene for guanylate cyclase–activating protein-1 (GCAP1) (GUCA1A) have been associat...
Mutations in the gene for guanylate cyclase-activating protein-1 (GCAP1) (GUCA1A) have been associat...
ABSTRACT: Rod outer segment membrane guanylate cyclase1 (ROS-GC1) is the original member of the memb...
GCAP1 stimulates photoreceptor guanylate cyclase (GC) in bleached vertebrate photoreceptors when [Ca...
Rod outer segment membrane guanylate cyclase1 (ROS-GC1) is the original member of the membrane guany...
Two recently identified missense mutations (p. L84F and p. I107T) in GUCA1A, the gene coding for gua...
Guanylate cyclase activating protein-1 (GCAP1) is required for activation of retinal guanylate cycla...
Guanylate cyclase activating protein 1 (GCAP1) is a neuronal Ca 2+ sensor (NCS) that regulates the a...
Progressive visual impairment leading to blindness is often associated with inherited retinal dystro...
Guanylate cyclase-activating protein 1 (GCAP1), encoded by the GUCA1A gene, is a neuronal calcium se...
Purpose Photoreceptor cells efficiently respond to changing light conditions on a millisecond times...
Guanylate Cyclase Activating Protein 1 (GCAP1) regulates the enzymatic activity of the photoreceptor...
The GUCA1A gene encodes the guanylate cyclase activating protein 1 (GCAP1) of mammalian rod and co...
Purpose Cone dystrophies are often associated with altered levels of calcium (Ca2+) and cyclic GMP ...
Cone dystrophy-related mutations in guanylate cyclase-activating protein 1 (GCAP1) are known to caus...
Mutations in the gene for guanylate cyclase–activating protein-1 (GCAP1) (GUCA1A) have been associat...
Mutations in the gene for guanylate cyclase-activating protein-1 (GCAP1) (GUCA1A) have been associat...
ABSTRACT: Rod outer segment membrane guanylate cyclase1 (ROS-GC1) is the original member of the memb...
GCAP1 stimulates photoreceptor guanylate cyclase (GC) in bleached vertebrate photoreceptors when [Ca...
Rod outer segment membrane guanylate cyclase1 (ROS-GC1) is the original member of the membrane guany...
Two recently identified missense mutations (p. L84F and p. I107T) in GUCA1A, the gene coding for gua...
Guanylate cyclase activating protein-1 (GCAP1) is required for activation of retinal guanylate cycla...