Background and aims The vasopressin analogue desmopressin has demonstrated efficacy in decreasing bleeding time by increasing the circulating levels of coagulation factor VIII and von Willebrand factor, but also by direct effects on platelets. Previous studies have demonstrated contrasting results regarding the effect of desmopressin on platelets in vitro. The aim of this study was to investigate the dose-response effects of in vitro desmopressin in whole blood. Our hypothesis was that desmopressin could increase platelet function in anticoagulated whole blood being stored up to 4 hours. Methods Desmopressin was administered with up to four different concentrations to venous whole blood, sampled with standard vacutainer tubes from 10 health...
markdownabstractDesmopressin (DDAVP) results in a temporary impravement in hemostasis and is therefo...
treatment of choice for patients with von Wille-brand’s disease and mild hemophilia A. This com-poun...
The template bleeding time is still the screening test for defects of platelet function, although it...
BACKGROUND AND OBJECTIVE: Desmopressin (DDAVP) may shorten bleeding time in patients with disorders ...
1-deamino-8-d-arginine vasopressin (desmopressin [DDAVP]) is clinically efficacious in patients with...
Background Patients undergoing major cardiothoracic surgery are subjected to dilution, owing to mass...
Stimulation with the vasopressin analogue desmopressin (DDAVP) of extrarenal arginine vasopressin (A...
Objective: Mild hypothermia (32-35 °C) impairs primary haemostasis and coagulation. Correction of th...
Mild hypothermia (34-35 °C) increases peri-operative blood loss. We have previously demonstrated the...
The objective of the work presented in this thesis was to explore the role of potential alternatives...
Desmopressin is frequently used in patients with bleeding disorders because of its prohaemostatic ef...
1. DDAVP (increasing VWF/FVIII) is the drug of choice for mild hemophilia A and VWD, and (by unclear...
Background Platelet dysfunction, including that caused by antiplatelet agents, increases the risk of...
Impairment of platelet function commonly occurs after cardiopulmonary bypass, and may result in subs...
Background: Blood loss after cardiac surgery can be caused by impaired platelet (PLT) function after...
markdownabstractDesmopressin (DDAVP) results in a temporary impravement in hemostasis and is therefo...
treatment of choice for patients with von Wille-brand’s disease and mild hemophilia A. This com-poun...
The template bleeding time is still the screening test for defects of platelet function, although it...
BACKGROUND AND OBJECTIVE: Desmopressin (DDAVP) may shorten bleeding time in patients with disorders ...
1-deamino-8-d-arginine vasopressin (desmopressin [DDAVP]) is clinically efficacious in patients with...
Background Patients undergoing major cardiothoracic surgery are subjected to dilution, owing to mass...
Stimulation with the vasopressin analogue desmopressin (DDAVP) of extrarenal arginine vasopressin (A...
Objective: Mild hypothermia (32-35 °C) impairs primary haemostasis and coagulation. Correction of th...
Mild hypothermia (34-35 °C) increases peri-operative blood loss. We have previously demonstrated the...
The objective of the work presented in this thesis was to explore the role of potential alternatives...
Desmopressin is frequently used in patients with bleeding disorders because of its prohaemostatic ef...
1. DDAVP (increasing VWF/FVIII) is the drug of choice for mild hemophilia A and VWD, and (by unclear...
Background Platelet dysfunction, including that caused by antiplatelet agents, increases the risk of...
Impairment of platelet function commonly occurs after cardiopulmonary bypass, and may result in subs...
Background: Blood loss after cardiac surgery can be caused by impaired platelet (PLT) function after...
markdownabstractDesmopressin (DDAVP) results in a temporary impravement in hemostasis and is therefo...
treatment of choice for patients with von Wille-brand’s disease and mild hemophilia A. This com-poun...
The template bleeding time is still the screening test for defects of platelet function, although it...