Identification of metabolites in non-targeted metabolomics continues to be a bottleneck in metabolomics studies in large human cohorts. Unidentified metabolites frequently emerge in the results of association studies linking metabolite levels to, for example, clinical phenotypes. For further analyses these unknown metabolites must be identified. Current approaches utilize chemical information, such as spectral details and fragmentation characteristics to determine components of unknown metabolites. Here, we propose a systems biology model exploiting the internal correlation structure of metabolite levels in combination with existing biochemical and genetic information to characterize properties of unknown molecules.Levels of 758 metabolites...
International audienceIn human health research, metabolic signatures extracted from metabolomics dat...
Metabolism is the set of chemical reactions that occur in living systems that make life possible [1]...
MOTIVATION: Metabolomics involves studies of a great number of metabolites, which are small molecule...
Identification of metabolites in non-targeted metabolomics continues to be a bottleneck in metabolom...
Recent genome-wide association studies (GWAS) with metabolomics data linked genetic variation in the...
<div><p>Recent genome-wide association studies (GWAS) with metabolomics data linked genetic variatio...
<p>A: Examples of how to determine pathway classifications based on the functional annotations of GG...
Diverse health challenges such as rising incidence of metabolic disease, rapid aging, and increasing...
Metabolomics is a rapidly evolving discipline that involves the systematic study of endogenous small...
Metabolomics is a powerful approach for discovering biomarkers and for characterizing the biochemica...
Metabolomics is a rapidly evolving discipline that involves the systematic study of endogenous small...
Metabolomics is a powerful approach for discovering biomarkers and for characterizing the biochemica...
Metabolites are intermediate molecules of metabolic processes such as sugars, amino acids, fatty aci...
Motivation: Metabolite profiling aims at an unbiased identification and quantification of all the me...
Both targeted and untargeted mass spectrometry-based metabolomics approaches are used to understand ...
International audienceIn human health research, metabolic signatures extracted from metabolomics dat...
Metabolism is the set of chemical reactions that occur in living systems that make life possible [1]...
MOTIVATION: Metabolomics involves studies of a great number of metabolites, which are small molecule...
Identification of metabolites in non-targeted metabolomics continues to be a bottleneck in metabolom...
Recent genome-wide association studies (GWAS) with metabolomics data linked genetic variation in the...
<div><p>Recent genome-wide association studies (GWAS) with metabolomics data linked genetic variatio...
<p>A: Examples of how to determine pathway classifications based on the functional annotations of GG...
Diverse health challenges such as rising incidence of metabolic disease, rapid aging, and increasing...
Metabolomics is a rapidly evolving discipline that involves the systematic study of endogenous small...
Metabolomics is a powerful approach for discovering biomarkers and for characterizing the biochemica...
Metabolomics is a rapidly evolving discipline that involves the systematic study of endogenous small...
Metabolomics is a powerful approach for discovering biomarkers and for characterizing the biochemica...
Metabolites are intermediate molecules of metabolic processes such as sugars, amino acids, fatty aci...
Motivation: Metabolite profiling aims at an unbiased identification and quantification of all the me...
Both targeted and untargeted mass spectrometry-based metabolomics approaches are used to understand ...
International audienceIn human health research, metabolic signatures extracted from metabolomics dat...
Metabolism is the set of chemical reactions that occur in living systems that make life possible [1]...
MOTIVATION: Metabolomics involves studies of a great number of metabolites, which are small molecule...