The metabolite produced by one enzyme in a metabolic pathway can be transferred to the next enzyme in the pathway by free diffusion via solution or by channelling in an enzyme-enzyme complex without prior release of the metabolite to solution. While metabolite channelling is known to occur in systems where stable multienzyme complexes form, conflicting views have been expressed as to its existence in pathways involving "soluble" enzymes. This thesis examines the kinetic evidence that has been presented in support of a direct (channelled) metabolite transfer between soluble enzymes in glycolysis and connected pathways. More specifically, transient-state kinetic studies have been performed to test the proposal that there is a channelled trans...
Metabolic channelling occurs when two enzymes that act on a common substrate pass that intermediate ...
Metabolic channelling occurs when two enzymes that act on a common substrate pass that intermediate ...
AbstractThere are continuing reports on the existence of complexes of sequential metabolic enzymes. ...
There are two fundamentally different ways by which a metabolite can be transferred between enzymes ...
Transient-state kinetic experiments and analyses have been performed to examine the validity of hith...
Steady-state and transient-state kinetic experiments have been performed to test the proposal that t...
Steady-state and transient-state kinetic experiments have been performed to test the proposal that t...
The catalytic interaction of glyceraldehyde‐3‐phosphate dehydrogenase with glyceraldehydes‐3‐phospha...
Theoretical and experimental evidence is presented which leads to a rejection of the proposal that t...
Computer modelling has been used to investigate the effect of direct transfer of metabolites between...
AbstractBrownian dynamics (BD) simulations test for channeling of the substrate, glyceraldehyde 3-ph...
88-100<p class="MsoNormal" style="tab-stops:387.0pt;mso-layout-grid-align:none; text-autospace:none...
Metabolite or substrate channeling is a direct transfer of metabolites from one enzyme to the next e...
Metabolite or substrate channeling is a direct transfer of metabolites from one enzyme to the next e...
<div><p>Metabolite or substrate channeling is a direct transfer of metabolites from one enzyme to th...
Metabolic channelling occurs when two enzymes that act on a common substrate pass that intermediate ...
Metabolic channelling occurs when two enzymes that act on a common substrate pass that intermediate ...
AbstractThere are continuing reports on the existence of complexes of sequential metabolic enzymes. ...
There are two fundamentally different ways by which a metabolite can be transferred between enzymes ...
Transient-state kinetic experiments and analyses have been performed to examine the validity of hith...
Steady-state and transient-state kinetic experiments have been performed to test the proposal that t...
Steady-state and transient-state kinetic experiments have been performed to test the proposal that t...
The catalytic interaction of glyceraldehyde‐3‐phosphate dehydrogenase with glyceraldehydes‐3‐phospha...
Theoretical and experimental evidence is presented which leads to a rejection of the proposal that t...
Computer modelling has been used to investigate the effect of direct transfer of metabolites between...
AbstractBrownian dynamics (BD) simulations test for channeling of the substrate, glyceraldehyde 3-ph...
88-100<p class="MsoNormal" style="tab-stops:387.0pt;mso-layout-grid-align:none; text-autospace:none...
Metabolite or substrate channeling is a direct transfer of metabolites from one enzyme to the next e...
Metabolite or substrate channeling is a direct transfer of metabolites from one enzyme to the next e...
<div><p>Metabolite or substrate channeling is a direct transfer of metabolites from one enzyme to th...
Metabolic channelling occurs when two enzymes that act on a common substrate pass that intermediate ...
Metabolic channelling occurs when two enzymes that act on a common substrate pass that intermediate ...
AbstractThere are continuing reports on the existence of complexes of sequential metabolic enzymes. ...