This thesis describes functional and structural studies of the human protein α1-microglobulin (A1M), an evolutionarily well-conserved 26 kDa plasma and tissue protein mainly synthesized in the liver. A1M belongs to the lipocalin protein family. Lipocalins share a very similar structur, an 8-stranded β-barrel forming a hydrophobic pocket. A1M has reductase and radical scavenging properties. A1M also binds the iron-containing heme-group, a lipophilic small compound found in many proteins and enzymes, but toxic in free form. A truncated form of A1M (t-A1M) catalyzes degradation of the heme-group. These properties give A1M antioxidative properties in human tissues. The research focus in this thesis has been to study the protection mechanisms of...
During bleeding the skin is subjected to oxidative insults from free heme and radicals, generated fr...
Oxidative stress is associated with many renal disorders, both acute and chronic, and has also been ...
Oxidative stress is associated with many renal disorders, both acute and chronic, and has also been ...
This thesis describes structural and functional studies of alpha-1-microglobulin (a1m), a 26 kDa pla...
Alpha-1-microglobulin (A1M) is a small protein found intra- and extracellularly in all tissues of ve...
Oxidative stress has been implicated as an important factor in the progression of many diseases. An ...
α1-microglobulin (A1M) is a 26 kDa plasma and tissue protein with reductase activity and radical- an...
α1-microglobulin (A1M) is found in all vertebrates including humans. A1M was, together with retinol-...
Alpha(1)-microglobulin is a 26 kDa plasma and tissue glycoprotein that belongs to the lipocalin prot...
Alpha-1-microglobulin (A1M), a small lipocalin protein found in plasma and tissues, has been identif...
a1-Microglobulin (a1m) is a 26 kDa plasma and tissue protein belonging to the lipocalin protein fami...
alpha(1)-Microglobulin is a 26-kd protein, widespread in plasma and tissues and well-conserved among...
During bleeding the skin is subjected to oxidative insults from free heme and radicals, generated fr...
Hemoglobin is the major oxygen-carrying system of the blood, but has many potentially dangerous side...
During bleeding the skin is subjected to oxidative insults from free heme and radicals, generated fr...
During bleeding the skin is subjected to oxidative insults from free heme and radicals, generated fr...
Oxidative stress is associated with many renal disorders, both acute and chronic, and has also been ...
Oxidative stress is associated with many renal disorders, both acute and chronic, and has also been ...
This thesis describes structural and functional studies of alpha-1-microglobulin (a1m), a 26 kDa pla...
Alpha-1-microglobulin (A1M) is a small protein found intra- and extracellularly in all tissues of ve...
Oxidative stress has been implicated as an important factor in the progression of many diseases. An ...
α1-microglobulin (A1M) is a 26 kDa plasma and tissue protein with reductase activity and radical- an...
α1-microglobulin (A1M) is found in all vertebrates including humans. A1M was, together with retinol-...
Alpha(1)-microglobulin is a 26 kDa plasma and tissue glycoprotein that belongs to the lipocalin prot...
Alpha-1-microglobulin (A1M), a small lipocalin protein found in plasma and tissues, has been identif...
a1-Microglobulin (a1m) is a 26 kDa plasma and tissue protein belonging to the lipocalin protein fami...
alpha(1)-Microglobulin is a 26-kd protein, widespread in plasma and tissues and well-conserved among...
During bleeding the skin is subjected to oxidative insults from free heme and radicals, generated fr...
Hemoglobin is the major oxygen-carrying system of the blood, but has many potentially dangerous side...
During bleeding the skin is subjected to oxidative insults from free heme and radicals, generated fr...
During bleeding the skin is subjected to oxidative insults from free heme and radicals, generated fr...
Oxidative stress is associated with many renal disorders, both acute and chronic, and has also been ...
Oxidative stress is associated with many renal disorders, both acute and chronic, and has also been ...