Pyrimidine bases are the central precursors for RNA and DNA, and their intracellular pools are determined by de novo, salvage and catabolic pathways. In eukaryotes, degradation of uracil has been believed to proceed only via the reduction to dihydrouracil. Using a yeast model, Saccharomyces kluyveri, we show that during degradation, uracil is not reduced to dihydrouracil. Six loci, named URC1-6 (for uracil catabolism), are involved in the novel catabolic pathway. Four of them, URC3,5, URC6, and URC2 encode urea amidolyase, uracil phosphoribosyltransferase, and a putative transcription factor, respectively. The gene products of URC1 and URC4 are highly conserved proteins with so far unknown functions and they are present in a variety of prok...
• Reductive catabolism of pyrimidine nucleotides occurs via a three-step pathway in which uracil is ...
Nitrogen is essential to biological processes and is present in all living systems. Thus, in nature,...
Uridine kinase (UK) and uracil phosphoribosyltransferase (UPRT) are enzymes in pyrimidine salvage pa...
Pyrimidine bases are the central precursors for RNA and DNA, and their intracellular pools are deter...
Purine and pyrimidine bases are the central precursors of DNA and RNA and theirintracellular concent...
Pyrimidines are important nucleic acid precursors which are constantly synthesized, degraded, and re...
Pyrimidines are important precursors for nucleic acids, and constantly synthesized and degraded in t...
The pyrimidine catabolic pathway is of crucial importance in cancer patients because it is involved ...
The pyrimidine catabolic pathway is of crucial importance in cancer patients because it is involved ...
This study focused on expression, purification and functional characterization of three key proteins...
Pyrimidine salvage pathways are essential to all cells. They provide a balance of RNA synthesis with...
Degradation of purines to uric acid is generally conserved among organisms, however, the end product...
Degradation of purines to uric acid is generally conserved among organisms, however, the end product...
<div><p>Degradation of purines to uric acid is generally conserved among organisms, however, the end...
<p>While the metabolic pathway of purine degradation is present in bacteria, fungi, plants and anima...
• Reductive catabolism of pyrimidine nucleotides occurs via a three-step pathway in which uracil is ...
Nitrogen is essential to biological processes and is present in all living systems. Thus, in nature,...
Uridine kinase (UK) and uracil phosphoribosyltransferase (UPRT) are enzymes in pyrimidine salvage pa...
Pyrimidine bases are the central precursors for RNA and DNA, and their intracellular pools are deter...
Purine and pyrimidine bases are the central precursors of DNA and RNA and theirintracellular concent...
Pyrimidines are important nucleic acid precursors which are constantly synthesized, degraded, and re...
Pyrimidines are important precursors for nucleic acids, and constantly synthesized and degraded in t...
The pyrimidine catabolic pathway is of crucial importance in cancer patients because it is involved ...
The pyrimidine catabolic pathway is of crucial importance in cancer patients because it is involved ...
This study focused on expression, purification and functional characterization of three key proteins...
Pyrimidine salvage pathways are essential to all cells. They provide a balance of RNA synthesis with...
Degradation of purines to uric acid is generally conserved among organisms, however, the end product...
Degradation of purines to uric acid is generally conserved among organisms, however, the end product...
<div><p>Degradation of purines to uric acid is generally conserved among organisms, however, the end...
<p>While the metabolic pathway of purine degradation is present in bacteria, fungi, plants and anima...
• Reductive catabolism of pyrimidine nucleotides occurs via a three-step pathway in which uracil is ...
Nitrogen is essential to biological processes and is present in all living systems. Thus, in nature,...
Uridine kinase (UK) and uracil phosphoribosyltransferase (UPRT) are enzymes in pyrimidine salvage pa...