TEDDY- The environmental determinants of diabetes in the young - An observational clinical trial

Hagopian, William A.
Lernmark, Åke
Rewers, Marian J.
Simell, Olli G.
She, Jin-Xiong
Ziegler, Anette G.
Krischer, Jeffrey P.
Akolkar, Beena

Open link

Publication date

January 2006

DOI

10.1196/annals.1375.049

Publisher

Wiley

ISSN

0077-8923

Citation count (estimate)

Abstract

The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and ...