The non-peptide ET-receptor antagonist Bosentan was used to investigate the role of endogenous endothelin-1 (ET-1) in the development of the Sephadex-induced lung inflammation in the rat. Intratracheal instillation of Sephadex caused a 60-fold rise in endothelin-1-like-immunoreactivity (ET-1-LI) in bronchoalveolar lavage fluid (BALF) concomitant with development of lung oedema, an influx of inflammatory cells into the airways and a rise in the protein content in BALF. The ET-1-LI level in lung homogenate was not significantly affected. Pre-treatment with Bosentan reduced ET-1-LI content in the lung parenchyma but increased ET-1-LI levels in BALF, possibly indicating an effective displacement of ET-1 from its receptors. In Bosentan-treated a...
Serum endothelin levels increase during sepsis, ischemia, reperfusion, pulmonary operations, and sys...
Endothelin-1 (ET-1) is known to have potent contractile and proliferative effects on vascular smooth...
Abstract: Endothelin peptides play active roles in different aspects of inflammation. This study inv...
Endothelin-1 (ET-1) is an extremely potent smooth muscle spasmogen well known from the vascular syst...
Idiopathic pulmonary fibrosis (IPF) belongs to the group of the interstitial lung diseases and is ch...
Endothelin 1 (ET-1) is a potent pulmonary vasoconstrictor and me-diator of lung diseases. Antagonism...
Aims and Methods: The pulmonary and vascular effects of endothelin-1 receptor activation were studie...
Cayir, Yasemin/0000-0001-9133-5460; Albayrak, Abdulmecit/0000-0002-1062-1965; UGAN, RUSTEM ANIL/0000...
Aims and Methods: The pulmonary and vascular effects of endothelin-1 receptor activation were studie...
Acute lung injury is a major clinical challenge in the intensive care unit. Sepsis is the most frequ...
The available treatment strategies against pulmonary hypertension include the administration of endo...
Dual endothelin ETA and ETB receptor antagonists are approved therapy for pulmonary artery hypertens...
The mechanism of Hypoxic Pulmonary Vasoconstriction is unknown. The role of endothelin-1 in hypoxic ...
endotoxemia: mRNA expression and vasoreactivity in pulmo-nary and systemic circulations. Am. J. Phys...
AbstractThe cysteinyl leukotrienes (cysLTs) and the peptide hormone endothelin (ET)-1 are potent bro...
Serum endothelin levels increase during sepsis, ischemia, reperfusion, pulmonary operations, and sys...
Endothelin-1 (ET-1) is known to have potent contractile and proliferative effects on vascular smooth...
Abstract: Endothelin peptides play active roles in different aspects of inflammation. This study inv...
Endothelin-1 (ET-1) is an extremely potent smooth muscle spasmogen well known from the vascular syst...
Idiopathic pulmonary fibrosis (IPF) belongs to the group of the interstitial lung diseases and is ch...
Endothelin 1 (ET-1) is a potent pulmonary vasoconstrictor and me-diator of lung diseases. Antagonism...
Aims and Methods: The pulmonary and vascular effects of endothelin-1 receptor activation were studie...
Cayir, Yasemin/0000-0001-9133-5460; Albayrak, Abdulmecit/0000-0002-1062-1965; UGAN, RUSTEM ANIL/0000...
Aims and Methods: The pulmonary and vascular effects of endothelin-1 receptor activation were studie...
Acute lung injury is a major clinical challenge in the intensive care unit. Sepsis is the most frequ...
The available treatment strategies against pulmonary hypertension include the administration of endo...
Dual endothelin ETA and ETB receptor antagonists are approved therapy for pulmonary artery hypertens...
The mechanism of Hypoxic Pulmonary Vasoconstriction is unknown. The role of endothelin-1 in hypoxic ...
endotoxemia: mRNA expression and vasoreactivity in pulmo-nary and systemic circulations. Am. J. Phys...
AbstractThe cysteinyl leukotrienes (cysLTs) and the peptide hormone endothelin (ET)-1 are potent bro...
Serum endothelin levels increase during sepsis, ischemia, reperfusion, pulmonary operations, and sys...
Endothelin-1 (ET-1) is known to have potent contractile and proliferative effects on vascular smooth...
Abstract: Endothelin peptides play active roles in different aspects of inflammation. This study inv...