Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
- Cornelis, M C
- Byrne, E M
- Esko, T
- Nalls, M A
- Ganna, A
- Paynter, N
- Monda, K L
- Amin, N
- Fischer, K
- Renström, Frida
- Ngwa, J S
- Huikari, V
- Cavadino, A
- Nolte, I M
- Teumer, A
- Yu, K
- Marques-Vidal, P
- Rawal, R
- Manichaikul, A
- Wojczynski, M K
- Vink, J M
- Zhao, J H
- Burlutsky, G
- Lahti, J
- Mikkilä, V
- Lemaitre, R N
- Eriksson, J
- Musani, S K
- Tanaka, T
- Geller, F
- Luan, J
- Hui, J
- Mägi, R
- Dimitriou, M
- Garcia, M E
- Ho, W-K
- Wright, M J
- Rose, L M
- Magnusson, P K E
- Pedersen, N L
- Couper, D
- Oostra, B A
- Hofman, A
- Ikram, M A
- Tiemeier, H W
- Uitterlinden, A G
- van Rooij, F J A
- Barroso, I
- Johansson, I
- Xue, L
- Kaakinen, M
- Milani, L
- Power, C
- Snieder, H
- Stolk, R P
- Baumeister, S E
- Biffar, R
- Gu, F
- Bastardot, F
- Kutalik, Z
- Jacobs, D R
- Forouhi, N G
- Mihailov, E
- Lind, L
- Lindgren, C
- Michaëlsson, K
- Morris, A
- Jensen, M
- Khaw, K-T
- Luben, R N
- Wang, J J
- Männistö, S
- Perälä, M-M
- Kähönen, M
- Lehtimäki, T
- Viikari, J
- Mozaffarian, D
- Mukamal, K
- Psaty, B M
- Döring, A
- Heath, A C
- Montgomery, G W
- Dahmen, N
- Carithers, T
- Tucker, K L
- Ferrucci, L
- Boyd, H A
- Melbye, M
- Treur, J L
- Mellström, D
- Hottenga, J J
- Prokopenko, I
- Tönjes, A
- Deloukas, P
- Kanoni, S
- Lorentzon, M
- Houston, D K
- Liu, Y
- Danesh, J
- Rasheed, A
- Mason, M A
- Zonderman, A B
- Franke, L
- Kristal, B S
- Karjalainen, J
- Reed, D R
- Westra, H-J
- Evans, M K
- Saleheen, D
- Harris, T B
- Dedoussis, G
- Curhan, G
- Stumvoll, M
- Beilby, J
- Pasquale, L R
- Feenstra, B
- Bandinelli, S
- Ordovas, J M
- Chan, A T
- Peters, U
- Ohlsson, C
- Gieger, C
- Martin, N G
- Waldenberger, M
- Siscovick, D S
- Raitakari, O
- Eriksson, J G
- Mitchell, P
- Hunter, D J
- Kraft, P
- Rimm, E B
- Boomsma, D I
- Borecki, I B
- Loos, R J F
- Wareham, N J
- Vollenweider, P
- Caporaso, N
- Grabe, H J
- Neuhouser, M L
- Wolffenbuttel, B H R
- Hu, F B
- Hyppönen, E
- Järvelin, M-R
- Cupples, L A
- Franks, Paul
- Ridker, P M
- van Duijn, C M
- Heiss, G
- Metspalu, A
- North, K E
- Ingelsson, E
- Nettleton, J A
- van Dam, R M
- Chasman, D I
DOIAbstract
Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-type coffee consumption (cups per day) among up to 91 462 coffee consumers of European ancestry with top single-nucleotide polymorphisms (SNPs) followed-up in ~30 062 and 7964 coffee consumers of European and African-American ancestry, respectively. Studies from both stages were combined in a trans-ethnic meta-analysis. Confirmed loci were examined for putative functional and biological relevance. Eight loci, including six novel loci, met GW significance (log10Bayes factor (BF)>5.64) with per-all...
Add to ORKG